Evidence map›Paper›PMID 29593412›Full record

ArticleInternational journal of nanomedicine2018

Kaempferol-immobilized titanium dioxide promotes formation of new bone: effects of loading methods on bone marrow stromal cell differentiation in vivo and in vitro.

Shuhei Tsuchiya, Keisuke Sugimoto, Hisanobu Kamio, Kazuto Okabe, Kensuke Kuroda, Masazumi Okido, Hideharu Hibi

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Flavonoid-Loaded Biomaterials in Bone Defect Repair.Molecules (Basel, Switzerland) · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shuhei TsuchiyaDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Keisuke SugimotoDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hisanobu KamioDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuto OkabeDepartment of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Kensuke KurodaInstitute of Materials and Systems for Sustainability, Nagoya University, Nagoya, Japan.
Masazumi OkidoInstitute of Materials and Systems for Sustainability, Nagoya University, Nagoya, Japan.
Hideharu HibiDepartment of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya University · JPNagoya University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurface modification of titanium dioxide (TiO

methodsThere were four experimental groups. Alkali-treated TiO

resultsKaempferol was detected on the surface of Al-cK and Al-aK. The results of the in vitro study showed that rBMSCs cultured on Al-cK and Al-aK promoted alkaline phosphatase activity, calcium deposition, and osteogenic differentiation. The in vivo histological analysis revealed that Al-cK and Al-aK stimulated new bone formation around implants.

conclusionTiO

Indexed as

AnimalsBone Marrow CellsBone RegenerationCell DifferentiationCell ProliferationCells, CulturedDental ImplantsFemaleFemurKaempferolsMesenchymal Stem CellsMicroscopy, Electron, ScanningOsseointegrationOsteogenesisRats, Sprague-DawleySpectrometry, X-Ray EmissionDental ImplantskaempferolKaempferolsTitaniumtitanium dioxidebiomaterialkaempferolsurface treatmenttitanium implant

Identifiers

PMID29593412
PMCPMC5865554
OpenAlexW2792505928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.