ArticleClinical interventions in aging2018
Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service - Health screening 11-year follow-up study.
Article in Clinical interventions in aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Accelerated biological aging based on DNA methylation clocks is a predictor of stroke occurrence: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Biological age acceleration and extrahepatic multimorbidity in U.S. adults with metabolic dysfunction-associated steatotic liver disease: a national cross-sectional study.Clinical and experimental hepatology · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Do we actually need aging clocks?npj aging · 2025Review
- No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.Signal transduction and targeted therapy · 2025Review
- Biological Age Acceleration Associated with the Progression Trajectory of Cardio-Renal-Metabolic Multimorbidity: A Prospective Cohort Study.Nutrients · 2025Article
- Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study.JMIR aging · 2025Article
- Article
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- AcidAGE: a biological age determination neural network based on urine organic acids.Biogerontology · 2024Article
- EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age.Aging and disease · 2024Article
- Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men's Health.International journal of molecular sciences · 2024Review
- Standardized multi-institutional data analysis of fixed and removable prosthesis: estimation of life expectancy with regards to variable risk factors.The journal of advanced prosthodontics · 2024Article
- LensAge index as a deep learning-based biological age for self-monitoring the risks of age-related diseases and mortality.Nature communications · 2023Article
- Review
- Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications.Brain sciences · 2023Article
- Association between kidney function and biological age: a China Health and Retirement Longitudinal Study.Frontiers in public health · 2023Article
- Article
- Biological Age Predictors: The Status Quo and Future Trends.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA comprehensive health index is needed to measure an individual's overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA) in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database. PATIENTS AND
methodsThis study was based on National Sample Cohort database of the National Health Insurance Service - Eligibility database and the National Health Insurance Service - Medical and Health Examination database of the year 2002 through 2013. BA model was developed based on the National Health Insurance Service - National Sample Cohort (NHIS - NSC) database and Cox proportional hazard analysis was done for mortality and major age-related disease incidence.
resultsFor every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6% (1.5% in men and 2.0% in women) and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (
conclusionEstimated BA by the developed BA model based on NHIS - NSC database is expected to be used not only as an index for assessing health and aging status and predicting mortality and major age-related disease incidence, but can also be applied to various health care fields.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.