ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Patterns of acute bilirubin encephalopathy in Nigeria: a multicenter pre-intervention study.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Neonatal phototherapy and cancer risk: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Prevalence of neonatal hyperbilirubinaemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood-type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Power of their stories: faces of kernicterus - experience and perception of caregivers and their children in Northern Nigeria.BMJ paediatrics open · 2026Article
- Yellow cerebrospinal fluid in an extremely preterm infant: a case report.Frontiers in cellular neuroscience · 2026Article
- Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout.Nature communications · 2025Article
- Modified Kramer's versus Kramer's Method for Clinical Assessment of Jaundice in Term and Near-Term Neonates.Indian journal of pediatrics · 2025Article
- Antenatal jaundice instruction and acute bilirubin encephalopathy in Nigeria.Pediatric research · 2024Article
- A Comparative Analysis of the Efficacy of Blood Exchange Therapy in Neonatal Hyperbilirubinemia Induced by ABO and Rh Incompatibility.International journal of general medicine · 2024Article
- Demystifying non-invasive approaches for screening jaundice in low resource settings: a review.Frontiers in pediatrics · 2023Review
- Article
- Detecting acute bilirubin encephalopathy in neonates based on multimodal MRI with deep learning.Pediatric research · 2022Article
- Review
- Establishment and Evaluation of Influencing Factors and Risk Prediction Model of Severe Neonatal Hyperbilirubinemia Complicated with Acute Bilirubin Encephalopathy.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Long-Term Effects of Biliverdin Reductase a Deficiency inAntioxidants (Basel, Switzerland) · 2021Article
- Review
- High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates.Italian journal of pediatrics · 2021Article
- Article
- Commentary on the Don Ostrow Trieste Yellow Retreat 2019: a successful biennium, what next?Pediatric research · 2020Article
- Quantitative proteomic characterization of microvesicles/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy.Molecular medicine reports · 2020Article
- Early prediction of adverse outcomes in infants with acute bilirubin encephalopathy.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute bilirubin encephalopathy (ABE) is an important cause of neonatal morbidity in Nigeria, accounting for 5-14% of neonatal deaths. Most newborns with severe ABE have irreversible damage before receiving treatment emphasizing the need for timely pre-admission monitoring and referral. There is limited evidence that educational interventions targeting mothers and health care providers will reduce delayed care.
objectiveTo provide baseline data on the incidence of ABE and associated pre-admission risk factors in five centers of Nigeria in order to evaluate the effect of subsequent educational interventions on outcome. STUDY
designThe incidence of ABE among newborns treated for hyperbilirubinemia was documented prospectively. Bivariate analysis and multivariate logistic regression were used to evaluate risk factors for acute bilirubin encephalopathy and reasons for regional differences in its occurrence.
resultsOf 1040 infants, 159 treated for hyperbilirubinemia (15.3%) had mild to severe bilirubin encephalopathy (including 35 deaths), but the incidence ranged from 7 to 22% between centers. Logistic regression identified four common predictors: total serum bilirubin (odds ratio 1.007 per mg/dl rise), out-of-hospital births (OR 2.6), non-alloimmune hemolytic anemia (OR 2.8), and delayed care seeking (OR 4.3).
conclusionThe high occurrence of bilirubin encephalopathy in Nigeria is due in large part to a delay in seeking care. A planned intervention strategy will target conditions leading to severe hyperbilirubinemia and delay.
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