Evidence map›Paper›PMID 29593338›Full record

ArticleBritish journal of cancer2018

The effect of selection and referral biases for the treatment of localised prostate cancer with surgery or radiation.

Christopher J D Wallis, Gerard Morton, Sender Herschorn, Ronald T Kodama, Girish S Kulkarni, Sree Appu, Bobby Shayegan, Roger Buckley, Arthur Grabowski, Steven A Narod and 1 more

Abstract read
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  3. Observational
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  11. Clinicopathological correlations and prognostic insights in osteosarcoma: a retrospective analysis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher J D WallisDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-5990-4026
Gerard MortonDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Sender HerschornDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Ronald T KodamaDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Girish S KulkarniDivision of Urology, University Health Network, University of Toronto, Toronto, Canada.
Sree AppuDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
Bobby ShayeganDivision of Urology, St. Josephs Healthcare, McMaster University, Hamilton, Canada.
Roger BuckleyDivision of Urology, North York General Hospital, University of Toronto, Toronto, Canada.
Arthur GrabowskiDivision of Urology, Durham Regional Cancer Centre, University of Toronto, Toronto, Canada.
Steven A NarodDepartment of Public Health Sciences, University of Toronto, Toronto, Canada.
Robert K NamDivision of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. Robert.nam@utoronto.ca.

Funding

CIHR
6 · The paper itself

Abstract

backgroundConsultation with radiation oncologists, in addition to urologists, is advocated for patients diagnosed with prostate cancer. Treatment patterns for patients receiving consultation from radiation oncologists in addition to urologists have not previously been described.

methodsWe conducted a matched cohort study of men with newly diagnosed non-metastatic prostate cancer in Ontario, Canada. Patients who underwent consultation with a radiation oncologist prior to treatment were matched 1:1 with patients managed by a urologist alone based on tumour and patient characteristics. We examined rates of active treatment (surgery or radiotherapy) within one year following diagnosis.

resultsAmong 5708 matched pairs (11,416 patients), those who received radiation oncology consultation were more likely to undergo active treatments whether they had intermediate or high-risk disease (88.6% vs. 65.9%, p < 0.0001; adjusted odds ratio 4.0, 95% CI: 3.6-4.4) or low-risk disease (56.1% vs. 13.3%, p < 0.0001; adjusted odds ratio 8.4, 95% CI: 6.7-10.6). This effect persisted after considering age, comorbidity, tumour volume and year of diagnosis.

conclusionsPatients newly diagnosed with prostate cancer who receive radiation oncology consultation are associated with a higher rate of active treatment, compared to patients managed by urologists only. Selection and referral biases, and unmeasured confounding such as patient preference must be considered as important factors attributing this association.

Indexed as

Patient SelectionAgedHumansMaleMiddle AgedOntarioPatient PreferencePractice Patterns, Physicians'ProstatectomyProstatic NeoplasmsReferral and ConsultationRiskSEER ProgramTreatment Outcome

Identifiers

PMID29593338
PMCPMC5959849

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.