ArticleScientific reports2018
Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Metabolomics, Molecular Networking and Phytochemical Investigation ofMolecules (Basel, Switzerland) · 2026Article
- A million shades of green: understanding and harnessing plant metabolic diversity.The EMBO journal · 2025Review
- Comprehensive, Quantitative Analysis of SRM 1950: the NIST Human Plasma Reference Material.Analytical chemistry · 2025Article
- Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential.PloS one · 2025Article
- Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment.Heliyon · 2024Review
- Plant Metabolomics: The Future of Anticancer Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Pharmaceutical Potential of Remedial Plants and Helminths for Treating Inflammatory Bowel Disease.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022.Pharmaceutics · 2023Review
- Article
- Natural Products Drug Discovery: On Silica or In-Silico?Handbook of experimental pharmacology · 2023Article
- Anti-Inflammatory Constituents ofMolecules (Basel, Switzerland) · 2022Article
- OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives.Frontiers in pharmacology · 2022Review
- Metabolites from halophilic bacterial isolates3 Biotech · 2021Article
- NMR Profiling ofMolecules (Basel, Switzerland) · 2021Article
- Article
- Natural products in drug discovery: advances and opportunities.Nature reviews. Drug discovery · 2021Review
- Metabolomic characterization of colorectal cancer cell lines highlighting stage-specific alterations during cancer progression.BioImpacts : BI · 2021Article
- Metabolic Profile and Evaluation of Biological Activities of Extracts from the Stems ofInternational journal of molecular sciences · 2020Article
- Bioactivity-Guided Fractionation and NMR-Based Identification of the Immunomodulatory Isoflavone from the Roots ofFoods (Basel, Switzerland) · 2019Article
- Spectroscopic Characterization and Cytotoxicity Assessment towards Human Colon Cancer Cell Lines of Acylated Cycloartane Glycosides fromMolecules (Basel, Switzerland) · 2019Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of bioactive compounds from natural sources entails an extremely lengthy process due to the timescale and complexity of traditional methodologies. In our study, we used a rapid NMR based metabolomic approach as tool to identify secondary metabolites with anti-proliferative activity against a panel of human colorectal cancer cell lines with different mutation profiles. For this purpose, fourteen Fabaceae species of Mediterranean vegetation were investigated using a double screening method:
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