ArticleScientific reports2018
Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Continuous multidimensional physiological monitoring redefines early warning and preemptive treatment for neutropenic sepsis following cisplatin chemotherapy in non-small cell lung cancer.Frontiers in pharmacology · 2026Article
- Smartphone based non invasive real time white blood cell counter leveraging blue light and static magnetic field.Scientific reports · 2025Article
- Depolarization diagrams for circularly polarized light scattering for biological particle monitoring.Journal of biomedical optics · 2024Article
- Usability Evaluation of a Noninvasive Neutropenia Screening Device (PointCheck) for Patients Undergoing Cancer Chemotherapy: Mixed Methods Observational Study.Journal of medical Internet research · 2022Observational
- Label-free automated neutropenia detection and grading using deep-ultraviolet microscopy.Biomedical optics express · 2021Article
- Exoscope-based videocapillaroscopy system forBiomedical optics express · 2021Article
- Scattering oblique plane microscopy forBiomedical optics express · 2021Article
- Automated White Blood Cell Counting in Nailfold Capillary Using Deep Learning Segmentation and Video Stabilization.Sensors (Basel, Switzerland) · 2020Article
- Imaging human blood cells in vivo with oblique back-illumination capillaroscopy.Biomedical optics express · 2020Article
- Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy.Biomedical optics express · 2020Article
- In-vivo full-field measurement of microcirculatory blood flow velocity based on intelligent object identification.Journal of biomedical optics · 2020Article
- Label-free characterization of white blood cells using fluorescence lifetime imaging and flow-cytometry: molecular heterogeneity and erythrophagocytosis [Invited].Biomedical optics express · 2019Article
- Automated detection of neutropenia using noninvasive video microscopy of superficial capillaries.American journal of hematology · 2019Article
- Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
Abstract
White-blood-cell (WBC) assessment is employed for innumerable clinical procedures as one indicator of immune status. Currently, WBC determinations are obtained by clinical laboratory analysis of whole blood samples. Both the extraction of blood and its analysis limit the accessibility and frequency of the measurement. In this study, we demonstrate the feasibility of a non-invasive device to perform point-of-care WBC analysis without the need for blood draws, focusing on a chemotherapy setting where patients' neutrophils-the most common type of WBC-become very low. In particular, we built a portable optical prototype, and used it to collect 22 microcirculatory-video datasets from 11 chemotherapy patients. Based on these videos, we identified moving optical absorption gaps in the flow of red cells, using them as proxies to WBC movement through nailfold capillaries. We then showed that counting these gaps allows discriminating cases of severe neutropenia (<500 neutrophils per µL), associated with increased risks of life-threatening infections, from non-neutropenic cases (>1,500 neutrophils per µL). This result suggests that the integration of optical imaging, consumer electronics, and data analysis can make non-invasive screening for severe neutropenia accessible to patients. More generally, this work provides a first step towards a long-term objective of non-invasive WBC counting.
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Registered trials
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