ArticleJournal of atherosclerosis and thrombosis2018
Interleukin-6 Level among Shift and Night Workers in Japan: Cross-Sectional Analysis of the J-HOPE Study.
Article in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Shift work and early vascular aging: a systematic review.BMC public health · 2026Pooled it
- High-Intensity Training Reduces CVD Risk Factors among Rotating Shift Workers: An Eight-Week Intervention in Industry.International journal of environmental research and public health · 2020Trial
- Body mass index links night work intensity with higher low-grade systemic inflammation: results from a field study in humans.International archives of occupational and environmental health · 2026Article
- Association between vitamin D deficiency and depressive symptoms among shift workers: Insights from network pharmacology and bioinformatics studies.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Night shift work and breast cancer: from etiopathology to precision risk analysis.NPJ breast cancer · 2025Review
- The positive association between evening or night work schedules and coronary heart disease or angina among U.S. adults: A cross-sectional study.American journal of preventive cardiology · 2025Article
- Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin.Current issues in molecular biology · 2025Review
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses.International journal of molecular sciences · 2025Article
- Sleep recovery ameliorates submandibular salivary gland inflammation associated with paradoxical sleep deprivation in male Wistar rats.Journal of applied oral science : revista FOB · 2025Article
- Sleep Duration, Number of Awakenings and Arterial Stiffness in Industrial Shift Workers: A Five-Week Follow-Up Study.International journal of environmental research and public health · 2022Article
- Factors Associated with the Work Engagement of Employees Working from Home during the COVID-19 Pandemic in Japan.International journal of environmental research and public health · 2021Article
- Circadian disruption and human health.The Journal of clinical investigation · 2021Review
- Why Lungs Keep Time: Circadian Rhythms and Lung Immunity.Annual review of physiology · 2020Review
- Review
- Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide.Frontiers in public health · 2020Article
- Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis.International journal of environmental research and public health · 2019Article
- A cross-sectional study on serum high-sensitivity C-reactive protein level and shift work among reproductive age women.Caspian journal of internal medicine · 2019Article
- Mental Stress, Anxiety and Depressive Symptoms and Interleuken-6 Level among Healthcare Workers during the COVID-19 Pandemic.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimShift workers have a high risk of cardiovascular disease (CVD). Systemic inflammation measured has been associated with the risk of CVD onset, in addition to classical risk factors. However, the association between work schedule and inflammatory cytokine levels remains unclear. The purpose of this study was to examine the association between work schedule and interleukin-6 (IL-6)/high-sensitivity C-reactive protein (hs-CRP) levels among Japanese workers.
methodsThe present cross-sectional study was a part of the Japanese Study of Health, Occupation and Psychosocial Factors Related Equity (J-HOPE). A total of 5259 persons who measured inflammatory cytokine were analyzed in this study. One-way analysis of variance was used to test log-transformed IL-6/hs-CRP differences by work schedule. Multiple regression analysis was used to examine the difference adjusted for other possible CVD risk factors.
resultsThere were 3660 participants who had a regular work schedule; the remaining schedules were shift work without night work for 181 participants, shift work with night work for 1276 participants, and only night work for 142 participants. The unadjusted model showed that only night workers were significantly related to high levels of IL-6 compared with regular workers. Even in the multiple regression analysis, the higher level of IL-6 among only night workers remained significant (β=0.058, P=0.01). On the contrary, hs-CRP was not.
conclusionThe present study revealed that only night shift work is significantly associated with high levels of IL-6 in Japanese workers. These observations help us understand the mechanism for the association between work schedule and CVD onset.
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