ArticleScience translational medicine2018
The impact of past vaccination coverage and immunity on pertussis resurgence.
Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Maternal pertussis immunization and the blunting of routine vaccine effectiveness: a meta-analysis and modeling study.Nature communications · 2024Pooled it
- Delayed introduction, transmission variation and susceptible dynamics explain spatial asynchrony during Republic of Korea's large pertussis outbreak.Journal of the Royal Society, Interface · 2026Article
- Quantifying the impact of vaccination on pertussis dynamics in Sweden.PLoS computational biology · 2026Article
- Sudden pertussis outbreaks in Guro-gu, Seoul: epidemiological characteristics and contributing factors in 2024.Child health nursing research · 2026Article
- Exploring the cause of the pertussis resurgence in England following the COVID-19 pandemic: a mathematical modelling study.BMC infectious diseases · 2026Article
- Understanding the Epidemiology and Contributing Factors of Post-COVID-19 Pertussis Outbreaks: A Narrative Review.Infectious diseases and therapy · 2026Review
- As pertussis returns to pre-COVID19 endemicity, vaccination remains our best ally against an evolvingEmerging microbes & infections · 2025Article
- Natural immune boosting biases pertussis infection estimates in seroprevalence studies.Nature communications · 2025Article
- Factors Associated with More Severe Disease in Infants and Children with Pertussis in the Post-Pandemic Era: A Single-Center Retrospective Study.Pathogens (Basel, Switzerland) · 2025Article
- Global, regional, and national burdens of pertussis among adults: a systematic analysis of age-specific trends using Global Burden of Diseases 2021 data.Infectious diseases of poverty · 2025Article
- Article
- Vaccine failure mode determines population-level impact of vaccination campaigns during epidemics.Journal of the Royal Society, Interface · 2025Article
- Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.Frontiers in public health · 2025Article
- Pertussis resurgence: epidemiological trends, pathogenic mechanisms, and preventive strategies.Frontiers in immunology · 2025Review
- Article
- Epidemiological and spatial-temporal clustering characteristics of pertussis in Southwest China, 2013-2024.Frontiers in public health · 2025Article
- Characterizing the interactions between influenza and respiratory syncytial viruses and their implications for epidemic control.Nature communications · 2024Article
- A novel outer membrane vesicle adjuvant improves vaccine protection against Bordetella pertussis.NPJ vaccines · 2024Article
- Development and validation of a diagnostic prediction model for children with pertussis.Scientific reports · 2024Article
- A multi-omics systems vaccinology resource to develop and test computational models of immunity.Cell reports methods · 2024Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
The resurgence of pertussis over the past decades has resulted in incidence levels not witnessed in the United States since the 1950s. The underlying causes have been the subject of much speculation, with particular attention paid to the shortcomings of the latest generation of vaccines. We formulated transmission models comprising competing hypotheses regarding vaccine failure and challenged them to explain 16 years of highly resolved incidence data from Massachusetts, United States. Our results suggest that the resurgence of pertussis is a predictable consequence of incomplete historical coverage with an imperfect vaccine that confers slowly waning immunity. We found evidence that the vaccine itself is effective at reducing overall transmission, yet that routine vaccination alone would be insufficient for elimination of the disease. Our results indicated that the core transmission group is schoolchildren. Therefore, efforts aimed at curtailing transmission in the population at large, and especially in vulnerable infants, are more likely to succeed if targeted at schoolchildren, rather than adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.