ArticleThe Journal of biological chemistry2018
Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.
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Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
49 citing papers in PubMed, 86 citations in OpenAlex.
- Fucose metabolism as a central axis linking inflammation, immunity, and cancer in the gut.Frontiers in immunology · 2026Review
- Structure, function, and implications of fucosyltransferases in health and disease.Nature communications · 2025Review
- Chemical Strategies to Custom-Modify α(1→3)-Fucosylated Glycan Motifs of the Human Glycocalyx.JACS Au · 2025Review
- Integrated 'omics analysis reveals human milk oligosaccharide biosynthesis programs in human lactocytes.iScience · 2025Article
- Realizing the promise of 'La Dolce Vita' via chemical biology: glycan-motif editing of sLeThe FEBS journal · 2025Review
- Article
- CD21Frontiers in immunology · 2025Article
- (Sialyl)Lewis Antigen Expression on Glycosphingolipids, N-, and O-Glycans in Colorectal Cancer Cell Lines is Linked to a Colon-Like Differentiation Program.Molecular & cellular proteomics : MCP · 2024Article
- Novel insight into FCSK-congenital disorder of glycosylation through a CRISPR-generated cell model.Molecular genetics & genomic medicine · 2024Article
- A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns.Journal of the American Chemical Society · 2024Article
- Let's Get Rolling: Precise Control of Microfluidic Assay Conditions to Recapitulate Selectin-Mediated Rolling Interactions of the Leukocyte Adhesion Cascade.Current protocols · 2024Article
- Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease.Journal of molecular medicine (Berlin, Germany) · 2024Article
- Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation.Nature communications · 2024Article
- The Multifaceted Role of FUT8 in Tumorigenesis: From Pathways to Potential Clinical Applications.International journal of molecular sciences · 2024Review
- Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer.Iranian journal of basic medical sciences · 2024Article
- MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- In-Depth Analysis of theInternational journal of molecular sciences · 2023Article
- Transcriptionally imprinted glycomic signatures of acute myeloid leukemia.Cell & bioscience · 2023Article
- Lewis x-carrying O-glycans are candidate modulators for conceptus attachment in pigs†.Biology of reproduction · 2023Article
- ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies.iScience · 2023Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Nandini MondalDepartment of Dermatology and Harvard Skin Disease Research Center, Boston, Massachusetts 02115; Program of Excellence in Glycosciences, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Brad DykstraDepartment of Dermatology and Harvard Skin Disease Research Center, Boston, Massachusetts 02115; Program of Excellence in Glycosciences, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Jungmin LeeProgram in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.
David J AshlineProgram of Excellence in Glycosciences, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Molecular, Cellular, and Biomedical Sciences, The Glycomics Center, University of New Hampshire, Durham, New Hampshire 03828.
Vernon N ReinholdProgram of Excellence in Glycosciences, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Molecular, Cellular, and Biomedical Sciences, The Glycomics Center, University of New Hampshire, Durham, New Hampshire 03828.
Derrick J RossiProgram in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.
Robert SacksteinDepartment of Dermatology and Harvard Skin Disease Research Center, Boston, Massachusetts 02115; Program of Excellence in Glycosciences, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115. Electronic address: rsackstein@partners.org.
Harvard University · USBrigham and Women's Hospital · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · US
Funding
REGULATION OF LACTOSAMINYL GLYCAN BIOSYNTHESIS IN HEMATOPOIETIC CELLSP01HL107146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SACKSTEIN, ROBERT · 2011 to 2017
$17.7MPreclinical development of gene-edited human hematopoietic stem cellsU19HL129903 · NHLBI · HARVARD UNIVERSITY · PI SCADDEN, DAVID T · 2015 to 2019
$11.5MIntegrating lipid genotyes and phenotypes in iPS derived hepatocytes/adipocytesU01HL107440 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI COWAN, CHAD ALBERT, DEO, RAHUL CHANDRAKANT · 2011 to 2015
$9.0MHumanized Mouse Avatars for T1DUC4DK104218 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, DALEY, GEORGE Q · 2014 to 2014
$4.1MReprogramming committed blood cells to a hematopoietic stem cell fateR01HL107630 · NHLBI · IMMUNE DISEASE INSTITUTE, INC. · PI ROSSI, DERRICK J. · 2011 to 2015
$2.5MNHLBI NIH HHS P01 HL107146NHLBI NIH HHS R01 HL107630NHLBI NIH HHS U01 HL107440NHLBI NIH HHS U19 HL129903NIDDK NIH HHS UC4 DK104218
Abstract
In humans, six α(1,3)-fucosyltransferases (α(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (Le
Indexed as
Amino SugarsFlow CytometryFucosyltransferasesGlycoconjugatesGlycomicsHumansIsoenzymesLewis X AntigenMass SpectrometryMesenchymal Stem CellsRNA, MessengerSialyl Lewis X AntigenAmino SugarsFucosyltransferasesFUT4 protein, humanGlycoconjugatesIsoenzymeslactosamineLewis X AntigenRNA, MessengerSialyl Lewis X AntigenE-selectin ligandfucosyltransferaseglycobiologyglycoengineeringLewis-Xmass spectrometry (MS)mesenchymal stem cells (MSCs)modified mRNAmRNAsialyl Lewis-X
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.