Evidence map›Paper›PMID 29593039›Full record

ArticleJournal of virology2018

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal

Carolina Garrido, Maria Abad-Fernandez, Marina Tuyishime, Justin J Pollara, Guido Ferrari, Natalia Soriano-Sarabia, David M Margolis

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 121 citations in OpenAlex.

  1. Increased Frequency of Dysfunctional Siglec-7Frontiers in immunology · 2021
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  10. CXCR6Frontiers in immunology · 2026
    Article
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  13. Review
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  16. Article
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  19. Article
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carolina GarridoUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Maria Abad-FernandezUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Marina TuyishimeDepartment of Surgery and Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Justin J PollaraDepartment of Surgery and Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Guido FerrariDepartment of Surgery and Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Natalia Soriano-SarabiaUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
David M MargolisUNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA dmargo@med.unc.edu.ORCID https://orcid.org/0000-0001-5714-0002
University of North Carolina at Chapel Hill · USDuke Medical Center · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigensK01OD024877 · OD · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2017 to 2019
$1.0M
Dual-Affinity Re-Targeting Proteins for Cure of Newborn Infant HIV-1 InfectionR21AI127022 · NIAID · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2016 to 2017
$437k
ImageStreamX Mark IIS10OD017984 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHER, NANCY C. · 2015 to 2015
$418k
NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI064518NIAID NIH HHS R21 AI127022NIAID NIH HHS T32 AI007392NIAID NIH HHS UM1 AI126619NIH HHS K01 OD024877NIH HHS S10 OD017984
6 · The paper itself

Abstract

Current efforts toward human immunodeficiency virus (HIV) eradication include approaches to augment immune recognition and elimination of persistently infected cells following latency reversal. Natural killer (NK) cells, the main effectors of the innate immune system, recognize and clear targets using different mechanisms than CD8

Indexed as

AdultAntibody-Dependent Cell CytotoxicityAnti-Retroviral AgentsCD4-Positive T-LymphocytesCells, CulturedHistone Deacetylase InhibitorsHIV-1HIV InfectionsHumansHydroxamic AcidsImmunotherapyInterferon-gammaInterleukin-15Killer Cells, NaturalLymphocyte ActivationReceptors, Natural Killer CellAnti-Retroviral AgentsHistone Deacetylase InhibitorsHydroxamic AcidsIL15 protein, humanInterferon-gammaInterleukin-15Receptors, Natural Killer CellVorinostatADCCHIVHIV eradicationhuman immunodeficiency virusIL-15immune functionimmunotherapyinterleukinskick and killlatency reversalnatural killer cellsNK cellSAHAshock and killVORvorinostat

Identifiers

PMID29593039
PMCPMC5974478
OpenAlexW2794490228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.