Evidence map›Paper›PMID 29593034›Full record

ArticleJournal of virology2018

Deaminase-Dead Mouse APOBEC3 Is an

Spyridon Stavrou, Wenming Zhao, Kristin Blouch, Susan R Ross

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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  2. Journal of virology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Spyridon StavrouDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA stavrou2@buffalo.edu.
Wenming ZhaoDepartment of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA.
Kristin BlouchDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Susan R RossDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3094-3769
University of Illinois Chicago · USUniversity of Pennsylvania · US

Funding

Role of APOBEC3 in in vivo Restriction of Retrovirus InfectionR01AI085015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 2010 to 2019
$3.9M
The in vivo function of A3A and A3G during retrovirus infectionF32AI100512 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STAVROU, SPYRIDON · 2013 to 2013
$54k
NIAID NIH HHS F32 AI100512NIAID NIH HHS R01 AI085015
6 · The paper itself

Abstract

The apolipoprotein B editing complex 3 (APOBEC3) proteins are potent retroviral restriction factors that are under strong positive selection, both in terms of gene copy number and sequence diversity. A common feature of all the members of the APOBEC3 family is the presence of one or two cytidine deamination domains, essential for cytidine deamination of retroviral reverse transcripts as well as packaging into virions. Several studies have indicated that human and mouse APOBEC3 proteins restrict retrovirus infection via cytidine deaminase (CD)-dependent and -independent means. To understand the relative contribution of CD-independent restriction

Indexed as

AnimalsCell LineCytidine DeaminaseDeaminationHEK293 CellsHumansLeukemia Virus, MurineMiceMice, Inbred C57BLMice, TransgenicRetroviridae InfectionsReverse Transcriptase InhibitorsReverse TranscriptionRNA-Directed DNA PolymeraseRNA, ViralApobec3 protein, mouseCytidine DeaminaseReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseRNA, ViralAPOBEC3cytidine deamination domainsMLVretrovirustransgenic micevirus pathogenesis

Identifiers

PMID29593034
PMCPMC5952145
OpenAlexW2790329146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.