Evidence map›Paper›PMID 29593031›Full record

ArticleJournal of virology2018

Central Role of the NF-κB Pathway in the

Bing Tian, Jun Yang, Yingxin Zhao, Teodora Ivanciuc, Hong Sun, Maki Wakamiya, Roberto P Garofalo, Allan R Brasier

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. RelA Signaling inInternational journal of molecular sciences · 2026
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  19. Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma.Advances in experimental medicine and biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bing TianDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Jun YangDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Yingxin ZhaoDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Teodora IvanciucDepartment of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.
Hong SunDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Maki WakamiyaInstitute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, USA.
Roberto P GarofaloSealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Allan R BrasierDepartment of Internal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA abrasier@wisc.edu.
The University of Texas Medical Branch at Galveston · USUniversity of Wisconsin–Madison · US

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
Virus, Tissue Culture and ImmunoassayP01AI062885 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CASOLA, ANTONELLA · 2005 to 2022
$23.9M
Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7M
NCATS NIH HHS UL1 TR001439NIAID NIH HHS P01 AI062885NIEHS NIH HHS P30 ES006676
6 · The paper itself

Abstract

Lower respiratory tract infection with respiratory syncytial virus (RSV) produces profound inflammation. Despite an understanding of the role of adaptive immunity in RSV infection, the identity of the major sentinel cells initially triggering inflammation is controversial. Here we evaluate the role of nonciliated secretoglobin (

Indexed as

Alveolar Epithelial CellsAnimalsBromodomain Containing ProteinsBronchiolesCell LineDEAD Box Protein 58FemaleHumansInflammationInterferon-gammaInterferon Regulatory Factor-1Interferon Regulatory Factor-7MaleMiceMice, Inbred C57BLMice, KnockoutBrd4 protein, mouseBromodomain Containing ProteinsDdx58 protein, mouseDEAD Box Protein 58Interferon-gammaInterferon Regulatory Factor-1Interferon Regulatory Factor-7Irf1 protein, mouseIrf7 protein, mouseNuclear ProteinsRela protein, mouseSCGB1A1 protein, humanTamoxifenTranscription Factor RelATranscription FactorsUteroglobinhistone acetyltransferaseIFNinnate immunitymucosal inflammationNF-κBrespiratory syncytial virusRSV

Identifiers

PMID29593031
PMCPMC5952137
OpenAlexW2791887519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.