Evidence map›Paper›PMID 29592961›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in

Xavier Michelet, Amit Tuli, Huixian Gan, Carolina Geadas, Mahak Sharma, Heinz G Remold, Michael B Brenner

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Xavier MicheletDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; atuli@imtech.res.in Xavier.michelet@agentustherapeutics.com mbrenner@research.bwh.harvard.edu.
Amit TuliDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; atuli@imtech.res.in Xavier.michelet@agentustherapeutics.com mbrenner@research.bwh.harvard.edu.ORCID 0000-0001-5476-4127
Huixian GanDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Carolina GeadasDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-9588-3675
Mahak SharmaDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4117-4790
Heinz G RemoldDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Michael B BrennerDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; atuli@imtech.res.in Xavier.michelet@agentustherapeutics.com mbrenner@research.bwh.harvard.edu.
Brigham and Women's Hospital · US

Funding

CD1d-restricted T Cell Self-antigens and InfectionR01AI063428 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2005 to 2015
$3.9M
Investigating the Role of the GTPase Arl8b in Plasma Membrane Repair of Mtb-Infected MacrophagesR21AI112766 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI REMOLD, HEINZ GERNOT · 2015 to 2016
$488k
DBT-Wellcome Trust India Alliance IA/I/12/1/500523DBT-Wellcome Trust India Alliance IA/I/14/2/501543NIAID NIH HHS R01 AI063428NIAID NIH HHS R21 AI112766Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADP-Ribosylation FactorsApoptosisCell MembraneHumansImmune EvasionLysosomesMacrophagesMycobacterium tuberculosisNecrosisTuberculosisVirulenceADP-Ribosylation FactorsARL8B protein, human

Identifiers

PMID29592961
PMCPMC5995332
OpenAlexW2795012276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.