ArticleBMJ (Clinical research ed.)2018
Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pharmacological interactions between psychotropic drugs and anticancer treatments: implications for clinical practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Use of sensitivity analyses to assess uncontrolled confounding from unmeasured variables in observational, active comparator pharmacoepidemiologic studies: a systematic review.American journal of epidemiology · 2025Pooled it
- Article
- Establishing a Validation Framework of Treatment Discontinuation in Claims Data Using Natural Language Processing and Electronic Health Records.Clinical pharmacology and therapeutics · 2025Article
- Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.Annals of internal medicine · 2023Article
- Delirium Screening and Pharmacotherapy in the ICU: The Patients Are Not the Only Ones Confused.Journal of clinical medicine · 2023Article
- Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization.JAMA network open · 2023Article
- Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database.BMJ open · 2022Observational
- An Analysis of Psychoactive Medications Initiated in the ICU but Continued Beyond Discharge: A Pilot Study of Stewardship.Journal of pharmacy practice · 2020Observational
- Association between antipsychotic use and acute ischemic heart disease in women but not in men: a retrospective cohort study of over one million primary care patients.BMC medicine · 2020Article
- Antipsychotics and the Risk of Mortality or Cardiopulmonary Arrest in Hospitalized Adults.Journal of the American Geriatrics Society · 2020Article
- Effect of the antipsychotic drug haloperidol on arrhythmias during acute myocardial infarction in a porcine model.International journal of cardiology. Heart & vasculature · 2020Article
- Independent discussion sections for improving inferential reproducibility in published research.British journal of anaesthesia · 2019Article
- Alzheimer's disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study.Alzheimer's & dementia (New York, N. Y.) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.
designCohort study using a healthcare database.
settingNationwide sample of patient data from more than 700 hospitals across the United States.
participants6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014.
main outcome measureIn-hospital mortality during seven days of follow-up from treatment initiation.
resultsAmong 6578 patients (mean age 75.2 years) treated with an oral antipsychotic drug, 1668 (25.4%) initiated haloperidol and 4910 (74.6%) initiated atypical antipsychotics. The mean time from admission to start of treatment (5.3
conclusionThe results suggest a small increased risk of death within seven days of initiating haloperidol compared with initiating an atypical antipsychotic in patients with acute myocardial infarction. Although residual confounding cannot be excluded, this finding deserves consideration when haloperidol is used for patients admitted to hospital with cardiac morbidity.
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