ArticleProceedings of the National Academy of Sciences of the United States of America2018
Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment.Brain and behavior · 2026Pooled it
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Incidental Learning: A Systematic Review of Its Effect on Episodic Memory Performance in Older Age.Frontiers in aging neuroscience · 2019Pooled it
- Review
- High-resolution MRI evidence for age- and sex-related changes in hippocampal subfield volume during healthy aging.GeroScience · 2026Article
- Surface expansion regionalization of the hippocampus in early brain development.Developmental cognitive neuroscience · 2026Article
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex Vivo Imaging Validated With Histology.Hippocampus · 2026Article
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Human brain mapping · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Microglial reactivity in the hippocampal CA2 is associated with advanced neuronal α-synucleinopathy.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Trajectory of stratum radiatum, lacunosum and moleculare integrity in Alzheimer's disease continuum.Scientific reports · 2026Article
- Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.bioRxiv : the preprint server for biology · 2025Article
- Harmonized Protocol for Segmentation of the Hippocampal Tail on High-ResolutionbioRxiv : the preprint server for biology · 2025Article
- Hippocampal grey matter changes across scales in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal subfields: volume, neuropathological vulnerability and cognitive decline in Alzheimer's and Parkinson's disease.Alzheimer's research & therapy · 2025Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- Absolute Number of Three Populations of Interneurons and All GABAergic Synapses in the Human Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Although the hippocampus is one of the most studied structures in the human brain, limited quantitative data exist on its 3D organization, anatomical variability, and effects of disease on its subregions. Histological studies provide restricted reference information due to their 2D nature. In this paper, high-resolution (∼200 × 200 × 200 μm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.