Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

1. Identification of PRRG1 as a possible molecular target of pancreatic cancer.Cell death & disease · 2026
   Article
2. Warfarin-GPRP: Development and Evaluation of a Novel Warfarin-Based Peptide Conjugate for Enhanced Anticoagulant Activity.ACS omega · 2026
   Article
3. Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions.Journal of evaluation in clinical practice · 2025
   Review
4. Impact of Antibacterials on the Quality of Anticoagulation Control in Patients Initiating Warfarin Therapy.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
   Observational
5. A Chinese patient with cardiogenic stroke and warfarin resistance: a case report.BMC neurology · 2025
   Article
6. Decoding Pulmonary Embolism: Pathophysiology, Diagnosis, and Treatment.Biomedicines · 2024
   Review
7. Drug-microbiota interactions: an emerging priority for precision medicine.Signal transduction and targeted therapy · 2023
   Review
8. The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS).The journal of cardiovascular aging · 2023
   Article
9. Frequency of prothrombin time-international normalized ratio monitoring and the long-term prognosis in patients with mechanical valve replacement.BMC cardiovascular disorders · 2023
   Observational
10. Multimodality approach to treat calciphylaxis in end-stage kidney disease patients.Renal failure · 2023
    Article
11. GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.Blood · 2022
    Article
12. Genetic Variation among Pharmacogenes in the Sardinian Population.International journal of molecular sciences · 2022
    Article
13. Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.International journal of molecular sciences · 2022
    Review
14. Potential clinical applications of phytopharmaceuticals for the in-patient management of coagulopathies in COVID-19.Phytotherapy research : PTR · 2022
    Review
15. Effects of Hyperglycemia and Diabetes Mellitus on Coagulation and Hemostasis.Journal of clinical medicine · 2021
    Review
16. Exon 2 skipping eliminates γ-glutamyl carboxylase activity, indicating a partial splicing defect in a patient with vitamin K clotting factor deficiency.Journal of thrombosis and haemostasis : JTH · 2019
    Article
17. Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu.Blood · 2018
    Article
18. VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues.Nutrients · 2018
    Review
19. Warfarin, a juggler's demise.Blood · 2018
    Article

Corrections and comments

• Commented on by
  Warfarin, a juggler's demise.2018

Authors and funding

6 authors at 1 institution in 1 country.

Funding

Abstract

Indexed as