Evidence map›Paper›PMID 29592873›Full record

ArticleBioscience reports2018

Atorvastatin ameliorates early brain injury through inhibition of apoptosis and ER stress in a rat model of subarachnoid hemorrhage.

Wentao Qi, Demao Cao, Yucheng Li, Aijun Peng, Youwei Wang, Kai Gao, Cunshan Tao, Yongkang Wu

Expression of concernOpen access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

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  13. Controlled Decompression Attenuates Brain Injury in a Novel Rabbit Model of Acute Intracranial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wentao QiDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Demao CaoDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Yucheng LiDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Aijun PengDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Youwei WangDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Kai GaoDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Cunshan TaoDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China.
Yongkang WuDepartment of Neurosurgery,The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China yongkangwu_1@126.com.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with very poor prognosis. The aim of the present study was to evaluate the protective effects of atorvastatin on early brain injury (EBI) after SAH using a perforation SAH model. Male Sprague-Dawley rats were randomly divided into four groups: the sham group, the SAH group (model group), SAH + 10 mg.kg

Indexed as

Administration, OralAnimalsAnticholesteremic AgentsApoptosisApoptosis Regulatory ProteinsAquaporin 4AtorvastatinBrainBrain InjuriesCaspase 3Disease Models, AnimalDrug RepositioningEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressGene Expression RegulationHeat-Shock ProteinsAnticholesteremic AgentsApoptosis Regulatory ProteinsAqp4 protein, ratAquaporin 4AtorvastatinCasp3 protein, ratCaspase 3Ddit3 protein, ratEndoplasmic Reticulum Chaperone BiPGRP78 protein, ratHeat-Shock ProteinsNeuroprotective AgentsTranscription Factor CHOPWaterapoptosisatorvastatincaspase-3subarachnoid hemorrhage

Identifiers

PMID29592873
PMCPMC5997796
OpenAlexW2794552175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.