Evidence map›Paper›PMID 29592782›Full record

ArticleMolecular pain

Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury.

Mu Xu, Zhigang Cheng, Zhuofeng Ding, Yunjiao Wang, Qulian Guo, Changsheng Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  18. The Role of the IL-4 Signaling Pathway in Traumatic Nerve Injuries.Neurorehabilitation and neural repair · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mu Xu1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Zhigang Cheng1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Zhuofeng Ding1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Yunjiao Wang1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Qulian Guo1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Changsheng Huang1 Department of Anesthesiology, Xiangya Hospital of Central South University, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol has been showed to relieve neuropathic pain through its anti-inflammatory effects on the peripheral nerve system. However, it is not clear whether resveratrol, especially when administered systemically, is effective in alleviating the peripheral neuropathy-induced imbalance between pro- and anti-inflammatory responses in the central nervous system. To test this, we used a rat neuropathic pain model resulting from chronic constriction injury of the sciatic nerve. Resveratrol (200 mg/kg) or vehicle (dimethylsulfoxide) were administered intraperitoneally once daily for 14 consecutive days after chronic constriction injury. We found that resveratrol attenuated mechanical allodynia and thermal hyperalgesia in rats with chronic constriction injury. After 14 days of resveratrol treatment, expression of several anti-inflammatory cytokine receptors, including IL-1RA and IL-1R2, was increased in the dorsal spinal cord of rats with chronic constriction injury, and IL-4Rα was increased in dorsal spinal cord neurons. Knockdown of IL-4Rα in a neuronal cell line reversed the resveratrol-induced upregulation of IL-1RA and IL-1R2. These results indicate that resveratrol enhances IL-4 receptor-mediated anti-inflammatory responses in the spinal cord and thus might contribute to the alleviation of central sensitization following peripheral nerve injury.

Indexed as

AnimalsAnti-Inflammatory AgentsConstrictionGene Knockdown TechniquesMaleModels, BiologicalNeuralgiaPC12 CellsRatsRats, Sprague-DawleyReceptors, Interleukin-4ResveratrolSciatic NeuropathySignal TransductionSpinal CordStilbenesAnti-Inflammatory AgentsReceptors, Interleukin-4ResveratrolStilbenesanti-inflammatory responsecentral sensitizationnerve injurypro-inflammatory responseResveratrol

Identifiers

PMID29592782
PMCPMC5881959
OpenAlexW2794579155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.