ArticleBiophysical journal2018
Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Uniform pore morphology of bijel-templated materials reduces cell circularity and inflammatory expression of macrophages.Materials today. Bio · 2026Article
- Topology Outweighs Stiffness: Self-Reinforced Cell Mechanotransduction via Multiaxial Curvature Engineering of Ultrasoft Hydrogels.ACS nano · 2026Article
- Regulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip array.Nature communications · 2025Article
- Anisotropic persistent random walk model simulates T-cells migration over curved landscapes.Scientific reports · 2025Article
- Understanding the relationship between pore structure and properties of triply periodic minimal surface bone scaffolds.Journal of materials science. Materials in medicine · 2025Review
- Curvature Perception of Mesenchymal Cells on Mesoscale Topographies.Advanced healthcare materials · 2025Article
- Diffusion model predicts the geometry of actin cytoskeleton from cell morphology.PLoS computational biology · 2024Article
- Influence of Titanium Surface Residual Stresses on Osteoblastic Response and Bacteria Colonization.Materials (Basel, Switzerland) · 2024Article
- The time dependent influence of curvature and topography of biomaterials in the behavior of corneal endothelial cells.Frontiers in bioengineering and biotechnology · 2024Article
- Effect of Porous Substrate Topographies on Cell Dynamics: A Computational Study.ACS biomaterials science & engineering · 2023Article
- Emergent collective organization of bone cells in complex curvature fields.Nature communications · 2023Article
- Printing channels with millimeter-scale curvature and deciphering their effect on the proliferation, morphology, orientation, and migration of M-22 cells.International journal of bioprinting · 2023Article
- Crypt-Villus Scaffold Architecture for Bioengineering Functional Human Intestinal Epithelium.ACS biomaterials science & engineering · 2022Article
- Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Epithelial cells adapt to curvature induction via transient active osmotic swelling.Developmental cell · 2022Article
- The 3D Genome: From Structure to Function.International journal of molecular sciences · 2021Review
- Curvature Induced by Deflection in Thick Meta-Plates.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Topological defects of integer charge in cell monolayers.Soft matter · 2021Article
- Normal cells repel WWOX-negative or -dysfunctional cancer cells via WWOX cell surface epitope 286-299.Communications biology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We show that substrates with nonzero Gaussian curvature influence the organization of stress fibers and direct the migration of cells. To study the role of Gaussian curvature, we developed a sphere-with-skirt surface in which a positive Gaussian curvature spherical cap is seamlessly surrounded by a negative Gaussian curvature draping skirt, both with principal radii similar to cell-length scales. We find significant reconfiguration of two subpopulations of stress fibers when fibroblasts are exposed to these curvatures. Apical stress fibers in cells on skirts align in the radial direction and avoid bending by forming chords across the concave gap, whereas basal stress fibers bend along the convex direction. Cell migration is also strongly influenced by the Gaussian curvature. Real-time imaging shows that cells migrating on skirts repolarize to establish a leading edge in the azimuthal direction. Thereafter, they migrate in that direction. This behavior is notably different from migration on planar surfaces, in which cells typically migrate in the same direction as the apical stress fiber orientation. Thus, this platform reveals that nonzero Gaussian curvature not only affects the positioning of cells and alignment of stress fiber subpopulations but also directs migration in a manner fundamentally distinct from that of migration on planar surfaces.
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