ArticleSchizophrenia bulletin2019
Probabilistic Category Learning and Striatal Functional Activation in Psychosis Risk.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries.Psychological medicine · 2025Article
- Global reward processing deficits predict negative symptoms transdiagnostically and transphasically in a severe mental illness-spectrum sample.European archives of psychiatry and clinical neuroscience · 2024Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Reinforcement learning profiles and negative symptoms across chronic and clinical high-risk phases of psychotic illness.European archives of psychiatry and clinical neuroscience · 2023Article
- Environmental context predicts state fluctuations in negative symptoms in youth at clinical high risk for psychosis.Psychological medicine · 2023Article
- Associations between long-term psychosis risk, probabilistic category learning, and attenuated psychotic symptoms with cortical surface morphometry.Brain imaging and behavior · 2022Article
- The Electroretinogram as a Potential Biomarker of Psychosis in Children at Familial Risk.Schizophrenia bulletin open · 2022Article
- What Is the Weather Prediction Task Good for? A New Analysis of Learning Strategies Reveals How Young Adults Solve the Task.Frontiers in psychology · 2022Article
- Reinforcement learning abnormalities in the attenuated psychosis syndrome and first episode psychosis.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Strategy Development and Feedback Processing During Complex Category Learning.Frontiers in psychology · 2021Article
- Evidence of reward system dysfunction in youth at clinical high-risk for psychosis from two event-related fMRI paradigms.Schizophrenia research · 2020Article
- Psychosis risk is associated with decreased white matter integrity in limbic network corticostriatal tracts.Psychiatry research. Neuroimaging · 2020Article
- Functional, Anatomical, and Morphological Networks Highlight the Role of Basal Ganglia-Thalamus-Cortex Circuits in Schizophrenia.Schizophrenia bulletin · 2020Article
- Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network.Cognitive, affective & behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPsychosis risk is associated with striatal dysfunction, including a previous behavioral study that found that psychosis risk is associated with impaired performance on a probabilistic category learning task (PCLT; ie, the Weather Prediction Task), a task strongly associated with striatal activation. The current study examined whether psychosis risk based on symptom levels was associated with both poor behavioral performance and task-related physiological dysfunction in specific regions of the striatum while performing the PCLT.
methodsThere were 2 groups of participants: psychosis risk (n = 21) who had both (a) extreme levels of self-reported psychotic-like beliefs and experiences and (b) interview-rated current attenuated psychotic symptoms (APS); and a comparison group (n = 20) who had average levels of self-reported psychotic-like beliefs and experiences. Participants completed the PCLT during fMRI scanning.
resultsThe current research replicated previous work finding behavioral PCLT deficits at the end of the task in psychosis risk. Furthermore, as expected, the psychosis risk group exhibited decreased striatal activation on the task, especially in the associative striatum. The psychosis risk group also displayed decreased activation in a range of cortical regions connected to the associative striatum. In contrast, the psychosis risk group exhibited greater activation predominantly in cortical regions not connected to the associative striatum.
conclusionsPsychosis risk was associated with both behavioral and striatal dysfunction during performance on the PCLT, suggesting that behavioral and imaging measures using this task could be a marker for psychosis risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.