ArticlePloS one2018
The draft genome of Kipferlia bialata reveals reductive genome evolution in fornicate parasites.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 41 citations in OpenAlex.
- The expanded genome of Hexamita inflata, a free-living diplomonad.Scientific data · 2025Article
- Extreme mitochondrial reduction in a novel group of free-living metamonads.Nature communications · 2024Article
- Transcriptome data sets of free-living diplomonads,Microbiology resource announcements · 2023Article
- Genomic survey maps differences in the molecular complement of vesicle formation machinery between Giardia intestinalis assemblages.PLoS neglected tropical diseases · 2023Article
- Spliceosomal introns in the diplomonad parasiteMicrobial genomics · 2023Article
- Draft Genome Sequence of Aduncisulcus paluster, a Free-Living Microaerophilic Eukaryote Belonging to the Fornicata.Microbiology resource announcements · 2023Article
- Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.BMC biology · 2022Article
- A myxozoan genome reveals mosaic evolution in a parasitic cnidarian.BMC biology · 2022Article
- Evidence for an Independent Hydrogenosome-to-Mitosome Transition in the CL3 Lineage of Fornicates.Frontiers in microbiology · 2022Article
- Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist.Nature communications · 2021Article
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- Retortamonads from vertebrate hosts share features of anaerobic metabolism and pre-adaptations to parasitism with diplomonads.Parasitology international · 2021Article
- Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia.Molecular biology and evolution · 2020Article
- Barthelonids represent a deep-branching metamonad clade with mitochondrion-related organelles predicted to generate no ATP.Proceedings. Biological sciences · 2020Article
- The compact genome ofMicrobial genomics · 2020Article
- Recent advances in understanding mitochondrial genome diversity.F1000Research · 2020Review
- The Oxymonad Genome Displays Canonical Eukaryotic Complexity in the Absence of a Mitochondrion.Molecular biology and evolution · 2019Article
- Lateral Acquisitions Repeatedly Remodel the Oxygen Detoxification Pathway in Diplomonads and Relatives.Genome biology and evolution · 2019Article
- Spliceosomal introns in Trichomonas vaginalis revisited.Parasites & vectors · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The fornicata (fornicates) is a eukaryotic group known to consist of free-living and parasitic organisms. Genome datasets of two model fornicate parasites Giardia intestinalis and Spironucleus salmonicida are well annotated, so far. The nuclear genomes of G. intestinalis assemblages and S. salmonicida are small in terms of the genome size and simple in genome structure. However, an ancestral genomic structure and gene contents, from which genomes of the fornicate parasites have evolved, remains to be clarified. In order to understand genome evolution in fornicates, here, we present the draft genome sequence of a free-living fornicate, Kipferlia bialata, the divergence of which is earlier than those of the fornicate parasites, and compare it to the genomes of G. intestinalis and S. salmonicida. Our data show that the number of protein genes and introns in K. bialata genome are the most abundant in the genomes of three fornicates, reflecting an ancestral state of fornicate genome evolution. Evasion mechanisms of host immunity found in G. intestinalis and S. salmonicida are absent in the K. bialata genome, suggesting that the two parasites acquired the complex membrane surface proteins on the line leading to the common ancestor of G. intestinalis and S. salmonicida after the divergence from K. bialata. Furthermore, the mitochondrion related organelles (MROs) of K. bialata possess more complex suites of metabolic pathways than those in Giardia and in Spironucleus. In sum, our results unveil the process of reductive evolution which shaped the current genomes in two model fornicate parasites G. intestinalis and S. salmonicida.
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