Evidence map›Paper›PMID 29590186›Full record

ArticlePloS one2018

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma.

Lucas de Lima Maia, Gabriela Tonini Peterle, Marcelo Dos Santos, Leonardo Oliveira Trivilin, Suzanny Oliveira Mendes, Mayara Mota de Oliveira, Joaquim Gasparini Dos Santos, Elaine Stur, Lidiane Pignaton Agostini, Cinthia Vidal Monteiro da Silva Couto and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Adrenomedullin in Tumorigenesis and Cancer Progression.International journal of molecular sciences · 2025
    Review
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  13. Effect of differential hypoxia-related gene expression on glioblastoma.The Journal of international medical research · 2021
    Article
  14. Article
  15. Review
  16. Histone DemethylaseOncoTargets and therapy · 2020
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Lucas de Lima MaiaPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.ORCID 0000-0002-0030-7913
Gabriela Tonini PeterlePrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Marcelo Dos SantosEscola Multicampi de Ciências Médicas do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Caicó, Rio Grande do Norte, Brazil.
Leonardo Oliveira TrivilinPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Suzanny Oliveira MendesPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Mayara Mota de OliveiraPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Joaquim Gasparini Dos SantosPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Elaine SturPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Lidiane Pignaton AgostiniPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Cinthia Vidal Monteiro da Silva CoutoPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Juliana DalbóPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Aricia Leone Evangelista Monteiro de AssisPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Anderson Barros ArchanjoPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Ana Maria Da Cunha MercanteDepartamento de Anatomia Patológica, Hospital Heliópolis, São Paulo, São Paulo, Brazil.
Rossana Veronica Mendoza LopezCentro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil.
Fábio Daumas NunesDepartamento de Patologia Bucal, Faculdade de Odontologia, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Marcos Brasilino de CarvalhoLaboratório de Biologia Molecular, Hospital Heliópolis, São Paulo, São Paulo, Brazil.
Eloiza Helena TajaraDepartamento de Biologia Molecular, Faculdade de Medicina, São José do Rio Preto, São Paulo, Brazil.
Iúri Drumond LouroPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Adriana Madeira Álvares-da-SilvaPrograma de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
Universidade Federal do Espírito Santo · BRHospital Heliópolis · BRFaculdade de Medicina de São José do Rio Preto · BRInstituto do Câncer do Estado de São Paulo · BRUniversidade de São Paulo · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsJumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. METHODS AND

resultsWe aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk.

conclusionJMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets.

Indexed as

AdrenomedullinBiomarkers, TumorCarcinoma, Squamous CellEpigenesis, GeneticFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHistonesHumansJumonji Domain-Containing Histone DemethylasesLymphatic MetastasisMaleMiddle AgedMouth NeoplasmsNeoplasm Recurrence, LocalOropharyngeal NeoplasmsADM protein, humanAdrenomedullinBiomarkers, TumorHistonesJumonji Domain-Containing Histone DemethylasesKDM3A protein, human

Identifiers

PMID29590186
PMCPMC5874045
OpenAlexW2795013187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.