ArticlePLoS neglected tropical diseases2018
Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Spatiotemporal epidemiology and clinical manifestations of two decades of scrub typhus in India: a systematic review and meta-analysis.BMJ global health · 2025Pooled it
- Review of the aetiologies of central nervous system infections in Vietnam.Frontiers in public health · 2024Pooled it
- Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality.PLoS neglected tropical diseases · 2022Pooled it
- Unveiling the unseen: generalized myoclonus status and MODS in scrub typhus, a case report and literature review.BMC infectious diseases · 2025Review
- Development and internal validation of clinical prediction models for scrub typhus and doxycycline-treatable causes in paediatric acute encephalitis syndrome in Karnataka, India: a multicentre, prospective study.The Lancet regional health. Southeast Asia · 2025Article
- Microbial Spectrum of Acute Encephalitis Syndrome With Special Reference to Non-Japanese Encephalitis Cases.Cureus · 2025Article
- Protocol for nationwide surveillance of Acute Encephalitis Syndrome (AES) in a network of tertiary care hospitals in India.BMC infectious diseases · 2025Article
- Article
- The second generation metagenomic sequencing of cerebrospinal fluid for diagnosis of non-eschar scrub typhus.Oxford medical case reports · 2025Article
- Clinical Profile and Long-Term Outcomes of Scrub Typhus Meningoencephalitis in Children.Cureus · 2025Article
- Etiology of Acute Encephalitis Syndrome in Adults in a Tertiary Care Center in Eastern Uttar Pradesh.The American journal of tropical medicine and hygiene · 2025Article
- Diagnostic markers of acute encephalitis syndrome and COVID-associated multisystem inflammatory syndrome in children from Southern India.Journal of medical virology · 2024Article
- CRISPR/Cas12a-Based Detection Platform for Early and Rapid Diagnosis of Scrub Typhus.Biosensors · 2023Article
- A case of acute encephalitis syndrome and cranial nerve palsy secondary to scrub typhus: A rare presentation from Western Nepal.Clinical case reports · 2023Article
- Association of Scrub Typhus in Children with Acute Encephalitis Syndrome and Meningoencephalitis, Southern India.Emerging infectious diseases · 2023Review
- Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India.PloS one · 2023Article
- Brain transcriptomics reveal the activation of neuroinflammation pathways during acuteFrontiers in immunology · 2023Article
- Diagnosis of Indigenous Non-Malarial Vector-Borne Infections from Malaria Negative Samples from Community and Rural Hospital Surveillance in Dhalai District, Tripura, North-East India.Diagnostics (Basel, Switzerland) · 2022Article
- Seasonal abundance of Leptotrombidium deliense, the vector of scrub typhus, in areas reporting acute encephalitis syndrome in Gorakhpur district, Uttar Pradesh, India.Experimental & applied acarology · 2021Article
- Seroprevalence trends of Scrub typhus among the febrile patients of Northern India: A prospective cross-sectional study.Journal of family medicine and primary care · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute Encephalitis Syndrome (AES) is a major seasonal public health problem in Bihar, India. Despite efforts of the Bihar health department and the Government of India, burden and mortality of AES cases have not decreased, and definitive etiologies for the illness have yet to be identified.
objectivesThe present study was undertaken to study the specific etiology of AES in Bihar.
methodsCerebrospinal fluid and/or serum samples from AES patients were collected and tested for various pathogens, including viruses and bacteria by ELISA and/or Real Time PCR.
findingsOf 540 enrolled patients, 33.3% (180) tested positive for at least one pathogen of which 23.3% were co-positive for more than one pathogen. Most samples were positive for scrub typhus IgM or PCR (25%), followed by IgM positivity for JEV (8.1%), WNV (6.8%), DV (6.1%), and ChikV (4.5%).M. tuberculosis and S. pneumoniae each was detected in ~ 1% cases. H. influenzae, adenovirus, Herpes Simplex Virus -1, enterovirus, and measles virus, each was detected occasionally. The presence of Scrub typhus was confirmed by PCR and sequencing. Bihar strains resembled Gilliam-like strains from Thailand, Combodia and Vietnam.
conclusionThe highlights of this pilot AES study were detection of an infectious etiology in one third of the AES cases, multiple etiologies, and emergence of O. tsutsugamushi infection as an important causative agent of AES in India.
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