ArticlePloS one2018
Serum vitamin D concentrations in hospitalized critically ill dogs.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Predictive value of physical and blood examination findings for short-term mortality in dogs with respiratory disorders.PloS one · 2025Article
- Efficacy of vitamin DThe British journal of nutrition · 2024Article
- Evaluation of serum 25-hydroxyvitamin D, C-reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis.Journal of veterinary internal medicine · 2023Article
- Serum 25-hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease.Journal of veterinary internal medicine · 2023Article
- Relationship between serum magnesium, calcium, and parathyroid concentrations in dogs with abnormally low serum 25-hydroxyvitamin D concentration and chronic or protein-losing enteropathy.Journal of veterinary internal medicine · 2023Article
- The effects of age, sex, breed, diet, reproductive status and housing condition on the amounts of 25(OH) vitamin D in the serum of healthy dogs: Reference values.Veterinary medicine and science · 2022Article
- Vitamin D status is heritable and under environment-dependent selection in the wild.Molecular ecology · 2022Article
- Serum 25-hydroxyvitamin D concentration and infectious respiratory disease complex in shelter dogs.Journal of veterinary internal medicine · 2021Article
- Rapid improvement in vitamin D status with dietary 25-hydroxycholecalciferol in vitamin D insufficient dogs.Journal of nutritional science · 2021Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs.Journal of veterinary internal medicine · 2020Article
- Article
- Effects of calcitriol on oxidative burst, phagocytic function, and leukocyte cytokine production in shelter dogs.Canine medicine and genetics · 2020Article
- Dysregulated serum concentrations of fat-soluble vitamins in dogs with chronic enteropathy.Journal of veterinary internal medicineArticle
- Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypovitaminosis D has been extensively documented in critically ill humans. However, whether or not critically ill dogs have alterations in vitamin D concentrations remains unconfirmed. The primary aims of our study were to compare serum 25-hydroxycholecalciferol [25(OH)D] concentrations in critically ill dogs with healthy control dogs, determine the prognostic utility of serum 25(OH)D concentration as a biomarker in critically ill dogs, and to assess if serum 25(OH)D concentrations in critically ill dogs are associated with length of stay in the intensive care unit or illness severity. Serum concentrations of 25(OH)D together with a range of other clinical, biochemical, and hematological parameters, were measured in 99 dogs within 24 hours of admission to the Intensive Care Unit (ICU). Critically ill dogs (P = 0.001) and dogs with sepsis (P = 0.002) had significantly lower serum 25(OH)D concentrations compared to healthy control dogs. In addition, serum 25(OH)D concentration was an independent predictor of in-hospital and 30 day survival. Using a cut-off of 33 ng/mL, serum 25(OH)D concentrations had excellent sensitivity (0.94; 95% CI, 0.71-1.00), but poor specificity (0.41; 95% CI, 0.31-0.53) for detection of survival. Serum 25(OH)D concentrations were inversely associated with acute patient physiologic and laboratory evaluation (APPLE) fast score but were not associated with ICU length of stay. Hospitalized dogs with critical illness have decreased serum 25(OH)D concentrations compared to healthy dogs and can be used to predict survival in this cohort.
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