ArticlePloS one2018
Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- Changes in the effective optical zone following hyperopic keratorefractive lenticule extraction.Annals of medicine · 2025Article
- Long-term follow-up of SMILE-derived corneal stromal lenticules preserved in nutrient capsules for treating corneal diseases.BMC ophthalmology · 2025Observational
- Comparative Analysis of Corneal Wound Healing: Differential Molecular Responses in Tears Following PRK, FS-LASIK, and SMILE Procedures.Biomedicines · 2024Article
- Applications of SMILE-extracted lenticules in ophthalmology.International journal of ophthalmology · 2024Review
- Femtosecond laser-assisted corneal transplantation with a low-energy, liquid-interface system.Scientific reports · 2022Article
- Comparison of clinical outcome of small-incision lenticule intrastromal keratoplasty and FS-LASIK for correction of moderate and high hyperopia.International journal of ophthalmology · 2022Article
- Femtosecond Laser-Assisted Small Incision Allogeneic Endokeratophakia Using a Hyperopic Lenticule in Rabbits.Translational vision science & technology · 2021Article
- Safety profiles of terahertz scanning in ophthalmology.Scientific reports · 2021Article
- Small incision lenticule extraction (SMILE) combined with allogeneic intrastromal lenticule inlay for hyperopia with astigmatism.PloS one · 2021Article
- Hyperopic laser keratorefractive surgery: Do steep corneas have worse outcomes?International ophthalmology · 2020Article
- Correction of hyperopia by intrastromal cutting and liquid filler injection.Journal of biomedical optics · 2019Article
- Tectonic keratoplasty using femtosecond laser lenticule in pediatric patients with corneal perforation secondary to blepharokeratoconjunctivitis: a case report and literature review.The Journal of international medical research · 2019Review
- Corneal remodelling and topography following biological inlay implantation with combined crosslinking in a rabbit model.Scientific reports · 2019Article
- Higher-Order-Aberrations Following Hyperopia Treatment: Small Incision Lenticule Extraction, Laser-Assisted In Situ Keratomileusis and Lenticule Implantation.Translational vision science & technology · 2018Article
- A Modified Small-Incision Lenticule Intrastromal Keratoplasty (sLIKE) for the Correction of High Hyperopia: A Description of a New Surgical Technique and Comparison to Lenticule Intrastromal Keratoplasty (LIKE).Medical hypothesis, discovery & innovation ophthalmology journal · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27μm LASIK, -45 ± 18μm SMILE and 28 ± 17μm Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted.
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