SynthesisPloS one2018
The impact of pharmacists-led medicines reconciliation on healthcare outcomes in secondary care: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- The effect of pharmacist-led interventions on the appropriateness and clinical outcomes of anticoagulant therapy: a systematic review and meta-analysis.European heart journal. Quality of care & clinical outcomes · 2024Pooled it
- Reducing medication errors for adults in hospital settings.The Cochrane database of systematic reviews · 2021Pooled it
- Effect of medication reconciliation interventions on outcomes: A systematic overview of systematic reviews.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2019Pooled it
- Effect of Medication Reconciliation at Hospital Admission on 30-Day Returns to Hospital: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Article
- AI-Based Automation for Medication Reconciliation: Scoping Review.Journal of medical Internet research · 2026Article
- Challenges in implementing pharmacist-led admission medication reconciliation in hospital practice: a qualitative study.BMC health services research · 2025Article
- Safe Staffing Standards for Pharmacy Technicians in Hospital Settings.Journal of market access & health policy · 2025Article
- Patterns of prescription, over-the-counter, and herbal medication use among pregnant women in Buraydah, Saudi Arabia: a cross-sectional study.Frontiers in pharmacology · 2025Article
- Evaluation of pharmacist-led medication reconciliation at county hospitals in China: A multicentre, open-label, assessor-blinded, nonrandomised controlled study.Journal of global health · 2024Article
- Council of Europe Resolution on the Implementation of Pharmaceutical Care-A Step Forward in Enhancing the Appropriate Use of Medicines and Patient-Centred Care.Healthcare (Basel, Switzerland) · 2024Article
- Impact of pharmacist-supported transition of care services in the Middle East and North Africa: a systematic review and meta-analysis.Journal of pharmaceutical policy and practice · 2024Review
- Effectiveness of pharmacist-led medication reconciliation on medication errors at hospital discharge and healthcare utilization in the next 30 days: a pragmatic clinical trial.Frontiers in pharmacology · 2024Article
- The impact of hospital-based post-discharge pharmacist medication review on patient clinical outcomes: A systematic review.Exploratory research in clinical and social pharmacy · 2023Article
- Community pharmacists' skills and practice regarding dispensing fiscalized substances: a cross-sectional survey.Frontiers in pharmacology · 2023Article
- Article
- Barriers and facilitators for the usage of a personal health record for medication reconciliation: A qualitative study among patients.British journal of clinical pharmacology · 2022Article
- The value of incorporating patient-consulted medication reconciliation in influencing drug-related actions in the outpatient rheumatology setting.BMC health services research · 2022Observational
- Pharmacist-led medication reconciliation at patient discharge: a tool to reduce healthcare utilization? an observational study in patients 65 years or older.BMC geriatrics · 2022Observational
- Differences in medication reconciliation interventions between six hospitals: a mixed method study.BMC health services research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse drug events (ADEs) impose a major clinical and cost burden on acute hospital services. It has been reported that medicines reconciliation provided by pharmacists is effective in minimizing the chances of hospital admissions related to adverse drug events.
objectiveTo update the previous assessment of pharmacist-led medication reconciliation by restricting the review to randomized controlled trials (RCTs) only.
methodsSix major online databases were sifted up to 30 December 2016, without inception date (Embase, Medline Ovid, PubMed, BioMed Central, Web of Science and Scopus) to assess the effect of pharmacist-led interventions on medication discrepancies, preventable adverse drug events, potential adverse drug events and healthcare utilization. The Cochrane tool was applied to evaluate the chances of bias. Meta-analysis was carried out using a random effects model.
resultsFrom 720 articles identified on initial searching, 18 RCTs (6,038 patients) were included. The quality of the included studies was variable. Pharmacists-led interventions led to an important decrease in favour of the intervention group, with a pooled risk ratio of 42% RR 0.58 (95% CI 0.49 to 0.67) P<0.00001 in medication discrepancy. Reductions in healthcare utilization by 22% RR 0.78 (95% CI 0.61 to 1.00) P = 0.05, potential ADEs by10% RR 0.90 (95% CI 0.78 to 1.03) P = 0.65 and preventable ADEs by 27% RR 0.73 (0.22 to 2.40) P = 0.60 were not considerable.
conclusionPharmacists-led interventions were effective in reducing medication discrepancies. However, these interventions did not lead to a significant reduction in potential and preventable ADEs and healthcare utilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.