ArticleScience (New York, N.Y.)2018
Translocation of a gut pathobiont drives autoimmunity in mice and humans.
Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02394964 (The Human Microbiome in Immune-Mediated Diseases), which is not on this map. Cited by 487 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
487citing papers in PubMed, 6 pooled it
32.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Human Microbiome in Immune-Mediated Diseases
Who cites it
487 citing papers in PubMed, 6 syntheses or guidelines pooled it, 805 citations in OpenAlex.
- Oral Microbiome in Systemic Autoimmune Diseases: A Systematic Review.Oral diseases · 2026Pooled it
- Coordinated oral-gut microbiota relocation in connective tissue diseases: a systematic review.Frontiers in immunology · 2026Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials.BMC medicine · 2024Pooled it
- Microbial dysbiosis in systemic lupus erythematosus: a scientometric study.Frontiers in microbiology · 2024Pooled it
- Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology.World journal of gastroenterology · 2023Trial
- Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.Gut microbes · 2026Article
- Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption.Gut microbes · 2026Article
- Gut microbiome and pregnancy complications: emerging evidence and mechanistic insights.Gut microbes · 2026Review
- Gut microbiota translocation and dissemination in health: can it be beneficial and purposeful?Gut microbes · 2026Review
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- Salmonella infection and biofilms drive anti-C1q and anti-dsDNA autoantibodies in systemic autoimmunity.PLoS pathogens · 2026Article
- Sex-dependent mechanisms in rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
- The causal association between inflammatory bowel disease and pancreatitis: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Intestinal and Blood-Brain Barrier Dysfunction in Lupus: Emerging Mechanisms and Modulation by Cinnamon.Molecules (Basel, Switzerland) · 2026Review
- Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.Cancer cell · 2026Article
427 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
17 authors at 2 institutions in 1 country.
S Manfredo VieiraDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8036-4223
M HiltenspergerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4600-1394
V KumarDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
D Zegarra-RuizDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0752-7238
C DehnerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5214-4813
N KhanDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2294-1173
F R C CostaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7131-6198
E TiniakouDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4749-870X
T GreilingDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0028-8986
W RuffDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5828-6425
A BarbieriDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2441-063X
C KriegelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
S S MehtaYale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3029-3217
J R KnightYale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1166-0437
D JainDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3845-0798
A L GoodmanDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7599-3471
M A KriegelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. martin.kriegel@yale.edu.ORCID 0000-0002-7371-0391
Yale University · USMicrobial ID (United States) · US
Funding
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MRenal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MTRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1MYale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2007 to 2017
$7.0MHuman Gut Commensal Cross-reactivity in Antiphospholipid SyndromeR01AI118855 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A., MEFFRE, ERIC · 2015 to 2019
$2.1MHigh Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890kRole of Gender-associated Microbiota in Organ-specific AutoimmunityK08AI095318 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A. · 2011 to 2015
$682kNCRR NIH HHS UL1 RR024139NIAID NIH HHS K08 AI095318NIAID NIH HHS R01 AI118855NIAID NIH HHS T32 AI007019NIAMS NIH HHS P30 AR053495NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK079310NIDDK NIH HHS T32 DK007017NIH HHS S10 OD018521
Abstract
Despite multiple associations between the microbiota and immune diseases, their role in autoimmunity is poorly understood. We found that translocation of a gut pathobiont,
Indexed as
Bacterial TranslocationGenetic Predisposition to DiseaseAnimalsAnti-Bacterial AgentsAutoantibodiesAutoimmune DiseasesAutoimmunityBacterial VaccinesDNA, BacterialEnterococcusGastrointestinal MicrobiomeHepatocytesHumansLiverMiceT-LymphocytesAnti-Bacterial AgentsAutoantibodiesBacterial VaccinesDNA, Bacterial
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT02394964ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.