ArticleNano letters2018
Light-Responsive Polymer Particles as Force Clamps for the Mechanical Unfolding of Target Molecules.
Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- NIR-Triggered Upconversion-Perovskite Heterostructures for Non-Genetic, Implant-Free Optoelectronic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification.Science advances · 2025Article
- Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution.ACS biomaterials science & engineering · 2023Article
- Functional nanoparticle-enabled non-genetic neuromodulation.Journal of nanobiotechnology · 2023Review
- Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of MechanosignalingNano letters · 2023Article
- Ensemble Force Spectroscopy by Shear Forces.Journal of visualized experiments : JoVE · 2022Article
- Programmable Mechanically Active Hydrogel-Based Materials.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Mechanical unfolding of ensemble biomolecular structures by shear force.Chemical science · 2021Article
- Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope.Nature communications · 2021Article
- Mechanical Stimulation of Adhesion Receptors Using Light-Responsive Nanoparticle Actuators Enhances Myogenesis.ACS applied materials & interfaces · 2020Article
- Variable incidence angle linear dichroism (VALiD): a technique for unique 3D orientation measurement of fluorescent ensembles.Optics express · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Single-molecule force spectroscopy techniques are powerful tools for investigating the mechanical unfolding of biomolecules. However, they are limited in throughput and require dedicated instrumentation. Here, we report a force-generating particle that can unfold target molecules on-demand. The particle consists of a plasmonic nanorod core encapsulated with a thermoresponsive polymer shell. Optical heating of the nanorod leads to rapid collapse of the polymer, thus transducing light into mechanical work to unfold target molecules. The illumination tunes the duration and degree of particle collapse, thus controlling the lifetime and magnitude of applied forces. Single-molecule fluorescence imaging showed reproducible mechanical unfolding of DNA hairpins. We also demonstrate the triggering of 50 different particles in <1 min, exceeding the speed of conventional atomic force microscopy. The polymer force clamp represents a facile and bottom-up approach to force manipulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.