ArticleJournal of neural engineering2018
Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 220 citations in OpenAlex.
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Review
- Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain-Machine Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in neuroprostheses: interfaces, materials, and applications.Nano convergence · 2026Review
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Why does invasive brain stimulation sometimes improve memory and sometimes impair it?PLoS biology · 2024Article
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- "In the spectrum of people who are healthy": Views of individuals at risk of dementia on using neurotechnology for cognitive enhancement.Neuroethics · 2024Article
- Functional and anatomical connectivity predict brain stimulation's mnemonic effects.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024Review
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories.Frontiers in computational neuroscience · 2024Article
- Adaptive octree meshes for simulation of extracellular electrophysiology.Journal of neural engineering · 2023Article
- Neuroprosthetics: from sensorimotor to cognitive disorders.Communications biology · 2023Review
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- ReplaceNet: real-time replacement of a biological neural circuit with a hardware-assisted spiking neural network.Frontiers in neuroscience · 2023Article
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- Flexibility of functional neuronal assemblies supports human memory.Nature communications · 2022Article
- Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWe demonstrate here the first successful implementation in humans of a proof-of-concept system for restoring and improving memory function via facilitation of memory encoding using the patient's own hippocampal spatiotemporal neural codes for memory. Memory in humans is subject to disruption by drugs, disease and brain injury, yet previous attempts to restore or rescue memory function in humans typically involved only nonspecific, modulation of brain areas and neural systems related to memory retrieval. APPROACH: We have constructed a model of processes by which the hippocampus encodes memory items via spatiotemporal firing of neural ensembles that underlie the successful encoding of short-term memory. A nonlinear multi-input, multi-output (MIMO) model of hippocampal CA3 and CA1 neural firing is computed that predicts activation patterns of CA1 neurons during the encoding (sample) phase of a delayed match-to-sample (DMS) human short-term memory task. MAIN
resultsMIMO model-derived electrical stimulation delivered to the same CA1 locations during the sample phase of DMS trials facilitated short-term/working memory by 37% during the task. Longer term memory retention was also tested in the same human subjects with a delayed recognition (DR) task that utilized images from the DMS task, along with images that were not from the task. Across the subjects, the stimulated trials exhibited significant improvement (35%) in both short-term and long-term retention of visual information. SIGNIFICANCE: These results demonstrate the facilitation of memory encoding which is an important feature for the construction of an implantable neural prosthetic to improve human memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.