Trial reportThe bone & joint journal2018
The effect of triclosan-coated sutures on the rate of surgical site infection after hip and knee arthroplasty: a double-blind randomized controlled trial of 2546 patients.
Trial report in The bone & joint journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Plus Sutures for preventing surgical site infection: a systematic review of clinical outcomes with economic and environmental models.BMC surgery · 2023Pooled it
- The role of triclosan-coated suture in preventing surgical infection: A meta-analysis.Joint diseases and related surgery · 2023Pooled it
- The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.BMJ open · 2019Pooled it
- Effect of triclosan-coated sutures on surgical site infections in pilonidal disease: prospective randomized study.International journal of colorectal disease · 2018Trial
- Not Every Draining Wound is Infection: Vicryl Reaction after Total Knee Arthroplasty Mimicking Prosthetic Joint Infection - A Case Series and Diagnostic Insights.Journal of orthopaedic case reports · 2026Article
- Epidemiological patterns, risk factors, and prevention gaps of surgical site infections in operating rooms: a hospital-based surveillance study.Frontiers in public health · 2026Article
- Consensus document on the management of wound closure in orthopaedic surgery.EFORT open reviews · 2025Review
- RISK FACTORS, PREVENTION, AND TREATMENT OF INFECTIONS RELATED TO TOTAL HIP ARTHROPLASTY: SYNTHESIS OF CLINICAL EVIDENCE.Acta ortopedica brasileira · 2025Review
- Expert Consensus on Best Practices for Optimal Wound Closure in Total Knee Arthroplasty: A STRIDE Initiative for Orthopedic Surgeons of India.Indian journal of orthopaedics · 2023Article
- Risk factors associated with surgical site infections following joint replacement surgery: a narrative review.Arthroplasty (London, England) · 2022Review
- Fragility Index as a Measure of Randomized Clinical Trial Quality in Adult Reconstruction: A Systematic Review.Arthroplasty today · 2021Article
- Multilayer Watertight Closure to Address Adverse Events From Primary Total Knee and Hip Arthroplasty: A Systematic Review of Wound Closure Methods by Tissue Layer.Arthroplasty today · 2021Article
- Prevention of infection in primary THA and TKA.EFORT open reviews · 2020Review
- Rigour will be important post-COVID-19.The bone & joint journal · 2020Article
- Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining.Journal of clinical medicine · 2020Review
- Prevention of Periprosthetic Joint Infection in Total Knee Arthroplasty: Main Studies Reported Between November 2017 and January 2020.The archives of bone and joint surgery · 2020Article
- Randomised controlled trial of triclosan coatedWorld journal of orthopedics · 2019Review
- Biomaterial suture Vicryl Plus reduces wound-related complications.Therapeutics and clinical risk management · 2018Article
- Integrated clinical pathways with watertight, multi-layer closure to improve patient outcomes in total hip and knee joint arthroplasty.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Surgical site infection (SSI) is a common complication of surgery with an incidence of about 1% in the United Kingdom. Sutures can lead to the development of a SSI, as micro-organisms can colonize the suture as it is implanted. Triclosan-coated sutures, being antimicrobical, were developed to reduce the rate of SSI. Our aim was to assess whether triclosan-coated sutures cause a reduction in SSIs following arthroplasty of the hip and knee. Patients and Methods: This two-arm, parallel, double-blinded study involved 2546 patients undergoing elective total hip (THA) and total knee arthroplasty (TKA) at three hospitals. A total of 1323 were quasi-randomized to a standard suture group, and 1223 being quasi-randomized to the triclosan-coated suture group. The primary endpoint was the rate of SSI at 30 days postoperatively. Results: The baseline characteristics of age, gender and comorbidities were well matched in the two groups. The rates of superficial SSI were 0.8% in the control group and 0.7% in the intervention group (p = 0.651), and when deep and superficial SSIs were combined the rates were 2.5% and 1.8 (p = 0.266). The length of stay in hospital and the rates of medical complications did not differ significantly between the groups (p = 1.000). Conclusion: This trial provided no evidence that the use of triclosan-coated sutures at THA and TKA leads to a reduction in the rate of SSI. Cite this article: Bone Joint J 2018;100-B:296-302.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.