Evidence map›Paper›PMID 29589303›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

The Colorectal Cancer Microenvironment: Strategies for Studying the Role of Cancer-Associated Fibroblasts.

Rahul Bhome, Massimiliano Mellone, Katherine Emo, Gareth J Thomas, A Emre Sayan, Alex H Mirnezami

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rahul BhomeCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK.
Massimiliano MelloneCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK.
Katherine EmoCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK.
Gareth J ThomasCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK.
A Emre SayanCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK.
Alex H MirnezamiCancer Research UK Centre, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton, UK. A.H.Mirnezami@soton.ac.uk.
Cancer Research UK · GBUniversity of Southampton · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Cancer Research UK 20526Cancer Research UK A20526Medical Research Council MR/R002061/1
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a key public health concern and the second highest cause of cancer related death in Western society. A dynamic interaction exists between CRC cells and the surrounding tumor microenvironment, which can stimulate not only the development of CRC, but its progression and metastasis, as well as the development of resistance to therapy. In this chapter, we focus on the role of fibroblasts within the CRC tumor microenvironment and describe some of the key methods for their study, as well as the evaluation of dynamic interactions within this biological ecosystem.

Indexed as

Tumor MicroenvironmentAnimalsCancer-Associated FibroblastsCoculture TechniquesColorectal NeoplasmsDisease ProgressionHumansLaser Capture MicrodissectionMiceMice, NudeMice, SCIDPrimary Cell CultureStromal CellsTumor Cells, CulturedXenograft Model Antitumor AssaysCancer-associated fibroblastsColorectal cancerExtracellular vesiclesTumor microenvironment

Identifiers

PMID29589303
PMCPMC5947757
OpenAlexW2792332186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.