ArticleTranslational stroke research2019
Genetic and Environmental Contributions to Variation in the Posterior Communicating Collaterals of the Circle of Willis.
Article in Translational stroke research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- A Ubiquitous Blood Flow Biomarker to Calculate Hypoxic-Ischemic Depolarization Latency in a Mouse Model of Focal Ischemic Stroke: Insight Into Metabolic and Electrophysiological Resilience.Translational stroke research · 2026Article
- SOD1 regulates CXCR4 transcription in cortical neurons for establishment of cerebral ischemic tolerance.Journal of advanced research · 2026Article
- Genetic determinants of insufficiency of the collateral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease.Cardiovascular research · 2025Article
- Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia intoTheranostics · 2025Article
- Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice.Experimental neurology · 2024Article
- Anatomical variations in the circle of Willis on magnetic resonance angiography in a south Trinidad population.BJR open · 2024Article
- Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Message to researchers: the characteristic absence of a posterior communicating artery is easily lost in the gerbil.Anatomical science international · 2023Article
- CCA repair or ECA ligation-Which middle cerebral artery occlusion is better in the reperfusion mouse model?Ibrain · 2023Article
- Collateral Supply in Preclinical Cerebral Stroke Models.Translational stroke research · 2022Review
- Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke.Scientific reports · 2021Article
- High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Article
- Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms.Stroke · 2020Article
- Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake.Experimental neurobiology · 2020Article
- Transient versus Permanent MCA Occlusion in Mice Genetically Modified to Have Good versus Poor Collaterals.Med one · 2019Article
- Sex Differences in the Cerebral Collateral Circulation.Translational stroke research · 2017Article
- Demographic age-related variation in Circle of Willis completeness assessed by digital subtraction angiography.Brain circulationArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Variation in blood flow mediated by the posterior communicating collateral arteries (PComs) contributes to variation in the severity of tissue injury in obstructive disease. Evidence in animals and humans indicates that differences in the extent of PComs, i.e., their anatomic lumen diameter and whether they are present bilaterally, unilaterally, or absent, are a major factor. These differences arise during development since they are present at birth. However, the causal mechanisms are unknown. We used angiography after maximal dilation to examine involvement of genetic, environmental, and stochastic factors. The extent of PComs varied widely among seven genetically diverse strains of mice. Like pial collaterals in the microcirculation, aging and hypertension reduced PCom diameter, while in contrast, obesity, hyperlipidemia, metabolic syndrome, and diabetes mellitus had no effect. Naturally occurring intrauterine growth restriction had no effect on extent of PCom or pial collaterals in the adult. The number and diameter of PComs evidenced much larger apparent stochastic-dependent variation than pial collaterals. In addition, both PComs underwent flow-mediated outward remodeling after unilateral permanent MCA occlusion that varied with genetic background and was greater on the ipsilesional side. These findings indicate that variation in the number and diameter of PCom collateral arteries arises from stochastic factors and naturally occurring genetic variants that differ from those that cause variation in pial collateral arterioles. Environmental factors also contribute: aging and hypertension reduce PCom diameter. Our results suggest possible sources of variation of PComs in humans and provide information relevant when studying mouse models of occlusive cerebrovascular disease.
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