SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018
Short- and Long-Term Oncological Outcome After Rectal Cancer Surgery: a Systematic Review and Meta-Analysis Comparing Open Versus Laparoscopic Rectal Cancer Surgery.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Mid- and low-rectal cancer: laparoscopic vs open treatment-short- and long-term results. Meta-analysis of randomized controlled trials.International journal of colorectal disease · 2022Pooled it
- Functional outcomes after laparoscopic versus robotic-assisted rectal resection: a systematic review and meta-analysis.Surgical endoscopy · 2021Pooled it
- Fast-track surgery nursing intervention in CRC patients with laparotomy and laparoscopic surgery.Medicine · 2022Trial
- Short- and Long-Term Outcomes of Open, Laparoscopic, and Robot-Assisted Surgery for Rectal Cancer.Annals of gastroenterological surgery · 2025Article
- Review
- A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience.Journal of clinical medicine · 2024Article
- Transanal total mesorectal excision (TaTME) in rectal cancer treatment within an expert center.Scientific reports · 2023Article
- Review
- Surgical site infection after laparoscopic resection of colorectal cancer is associated with compromised long-term oncological outcome.World journal of surgical oncology · 2022Article
- Transrectal endoscopic drainage with vacuum-assisted therapy in patients with anastomotic leaks following rectal cancer resection.Surgical endoscopy · 2022Article
- Postoperative non-steroidal anti-inflammatory drug use and oncological outcomes of rectal cancer.BJS open · 2021Article
- Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches.World journal of gastroenterology · 2020Review
- Real-world impact of laparoscopic surgery for rectal cancer: a population-based analysis.Current oncology (Toronto, Ont.) · 2020Article
- Prospective evaluation of muscle strength and spine joint motility of patients who underwent surgery for colorectal cancer by open and laparoscopic methods.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2020Article
- Laparoscopic Approach to Rectal Cancer-The New Standard?Frontiers in oncology · 2020Review
- Is there still a place for open surgery in the treatment strategy of rectal cancer?Przeglad gastroenterologiczny · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile several trials have compared laparoscopic to open surgery for colon cancer showing similar oncological results, oncological quality of laparoscopic versus open rectal resection is not well investigated.
methodsA systematic literature search for randomized controlled trials was conducted in MEDLINE, the Cochrane Library, and Embase. Qualitative and quantitative meta-analyses of short-term (rate of complete resections, number of harvested lymph nodes, circumferential resection margin positivity) and long-term (recurrence, disease-free and overall survival) oncologic results were conducted.
resultsFourteen randomized controlled trials were identified including 3528 patients. Patients in the open resection group had significantly more complete resections (OR 0.70; 95% CI 0.51-0.97; p = 0.03) and a higher number of resected lymph nodes (mean difference - 0.92; 95% CI - 1.08 to 0.75; p < 0.001). No differences were detected in the frequency of positive circumferential resection margins (OR 0.82; 95% CI 0.62-1.10; p = 0.18). Furthermore, no significant differences of long-term oncologic outcome parameters after 5 years including locoregional recurrence (OR 0.95; 95% CI 0.44-2.05; p = 0.89), disease-free survival (OR 1.16; 95% CI 0.84-1.58; p = 0.36), and overall survival (OR 1.04; 95% CI 0.76-1.41; p = 0.82) were found. Most trials exhibited a relevant risk of bias and several studies provided no information on the surgical expertise of the participating surgeons.
conclusionDifferences in oncologic outcome between laparoscopic and open rectal surgery for rectal cancer were detected for the complete resection rate and the number of resected lymph nodes in favor of the open approach. No statistically significant differences were found in oncologic long-term outcome parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.