Evidence map›Paper›PMID 29589201›Full record

ArticleJournal of molecular neuroscience : MN2018

The Potential Role of Toll-Like Receptor 4 in Mediating Dopaminergic Cell Loss and Alpha-Synuclein Expression in the Acute MPTP Mouse Model of Parkinson's Disease.

Giuseppina Mariucci, Rita Pagiotti, Francesco Galli, Luigina Romani, Carmela Conte

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Giuseppina MariucciDepartment of Pharmaceutical Sciences, University of Perugia, 06126, Perugia, Italy.
Rita PagiottiDepartment of Pharmaceutical Sciences, University of Perugia, 06126, Perugia, Italy.
Francesco GalliDepartment of Pharmaceutical Sciences, University of Perugia, 06126, Perugia, Italy.
Luigina RomaniDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Carmela ConteDepartment of Pharmaceutical Sciences, University of Perugia, 06126, Perugia, Italy. carmela.conte@unipg.it.ORCID http://orcid.org/0000-0003-2456-6300
University of Perugia · IT

Funding

Fondazione Cassa di Risparmio di Perugia 2016.0031.021
6 · The paper itself

Abstract

Toll-like receptors (TLRs) may have a role in Parkinson's disease (PD). In this study, we aimed at investigating the dopaminergic cell loss and alpha-synuclein (α-SYN) expression in TLR4-deficient mice (TLR4

Indexed as

alpha-SynucleinAnimalsBrainDopaminergic NeuronsGATA2 Transcription FactorMaleMiceMice, Inbred C57BLMPTP PoisoningToll-Like Receptor 4alpha-SynucleinGata2 protein, mouseGATA2 Transcription FactorTlr4 protein, mouseToll-Like Receptor 4Alpha-synucleinGATA2Parkinson’s diseaseThyrosine hydroxylaseToll-like receptor 4

Identifiers

PMID29589201
OpenAlexW2794542338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.