Evidence map›Paper›PMID 29589198›Full record

GuidelineHepatology international2018

Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype.

Paul Adams, Albert Altes, Pierre Brissot, Barbara Butzeck, Ioav Cabantchik, Rodolfo Cançado, Sonia Distante, Patricia Evans, Robert Evans, Tomas Ganz and 20 more

Abstract readPractice Guideline
In one paragraph

Guideline in Hepatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Recent Advances in Research on Iron Metabolism, Ferritin, and Hepcidin.International journal of molecular sciences · 2026
    Pooled it
  2. Pooled it
  3. [Chinese guidelines for the diagnosis and treatment of hereditary hemochromatosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Guideline
  4. Article
  5. Review
  6. Article
  7. Article
  8. Haemochromatosis revisited.World journal of hepatology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Prolonged exposure to welding fumes as a novel cause of systemic iron overload.Liver international : official journal of the International Association for the Study of the Liver · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Paul AdamsUniversity Hospital, Western University, London, ON, Canada.
Albert AltesAsociación Española de Hemocromatosis, Santa Coloma, Spain.
Pierre BrissotInserm Unit 1241, University Hospital Pontchaillou, Rennes, France. pierre.brissot@univ-rennes1.fr.
Barbara ButzeckHI - Haemochromatosis International, London, UK.
Ioav CabantchikInternational Bioiron Society, Schaumburg, USA.
Rodolfo CançadoDivision of Hematology, Santa Casa Medical School of Sao Paulo, Sao Paulo, SP, Brazil.
Sonia DistanteDepartment of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Patricia EvansHI - Haemochromatosis International, London, UK.
Robert EvansHI - Haemochromatosis International, London, UK.
Tomas GanzDavid Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Domenico GirelliDepartment of Medicine, University of Verona Veneto Region Referral Center for Iron Metabolism Disorders, Verona, Italy.
Rolf HultcrantzDepartment of Medicine, Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Stockholm, Sweden.
Gordon McLarenDivision of Hematology/Oncology, University of California, Irvine, CA, USA.
Ben MarrisHI - Haemochromatosis International, London, UK.
Nils MilmanDanish Haemochromatosis Association, Copenhagen, Denmark.
Elizabeta NemethCenter for Iron Disorders, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Peter NielsenInstitut für Biochemie und Molekulare Zellbiologie, University Medical Center Hamburg, Hamburg, Germany.
Brigitte PineauFédération Française des Associations de Malades de l'hémochromatose, Paris, France.
Alberto PipernoDepartment of Medicine and Surgery, Centre for Rare Diseases, University of Milano-Bicocca, Monza, Italy.
Graça PortoIBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
Dianne PrinceHI - Haemochromatosis International, London, UK.
John RyanOxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
Mayka SanchezAsociación Española de Hemocromatosis, Santa Coloma, Spain.
Paulo SantosHI - Haemochromatosis International, London, UK. paulo.caleb@unifesp.br.
Dorine SwinkelsDepartment of Laboratory Medicine, Radboudumc, Nijmegen, The Netherlands.
Emerência TeixeiraHI - Haemochromatosis International, London, UK.
Ketil ToskaHI - Haemochromatosis International, London, UK.
Annick VancloosterUniversity Hospitals Leuven, Gasthuisberg, Louvain, Belgium.
Desley WhiteHI - Haemochromatosis International, London, UK.
Contributors and Hemochromatosis International Taskforce

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of recommendations about therapeutic aspects of HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype, based on the published scientific studies and guidelines, in a form that is reasonably comprehensible to patients and people without medical training. This final version was approved at the Hemochromatosis International meeting on 12th May 2017 in Los Angeles.

Indexed as

HemochromatosisChelation TherapyDietFemaleHemochromatosis ProteinHomozygoteHumansMalePhlebotomyHemochromatosis Protein

Identifiers

PMID29589198
PMCPMC5904234

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.