Evidence map›Paper›PMID 29589117›Full record

ArticlePflugers Archiv : European journal of physiology2018

The degenerin region of the human bile acid-sensitive ion channel (BASIC) is involved in channel inhibition by calcium and activation by bile acids.

Alexandr V Ilyaskin, Sonja A Kirsch, Rainer A Böckmann, Heinrich Sticht, Christoph Korbmacher, Silke Haerteis, Alexei Diakov

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Bile acids and salt-sensitive hypertension: a role of the gut-liver axis.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  4. Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alexandr V IlyaskinInstitut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstr. 6, 91054, Erlangen, Germany.
Sonja A KirschComputational Biology, Department Biologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Rainer A BöckmannComputational Biology, Department Biologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Heinrich StichtAbteilung für Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Christoph KorbmacherInstitut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstr. 6, 91054, Erlangen, Germany.
Silke HaerteisInstitut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstr. 6, 91054, Erlangen, Germany. silke.haerteis@fau.de.ORCID 0000-0002-9440-3307
Alexei DiakovInstitut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstr. 6, 91054, Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bile acid-sensitive ion channel (BASIC) is a member of the ENaC/degenerin family of ion channels. It is activated by bile acids and inhibited by extracellular Ca

Indexed as

Amino Acid SequenceAnimalsBileBile Acids and SaltsCalciumDegenerin Sodium ChannelsHumansIon Channel GatingMolecular Docking SimulationOocytesXenopus laevisBile Acids and SaltsCalciumDegenerin Sodium ChannelsBASICBile acidsCa2+Degenerin siteMolecular dynamics (MD) simulationsTauro-deoxycholic acid

Identifiers

PMID29589117
OpenAlexW2794854420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.