ReviewEpilepsia open2017
Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications.
Review in Epilepsia open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prevalence, characteristics, and treatment outcomes of epilepsy in Nigeria: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?PLoS neglected tropical diseases · 2021Pooled it
- Meta-analysis of epilepsy prevalence in West Africa and its relationship with onchocerciasis endemicity and control.International health · 2020Pooled it
- Spatio-temporal analysis and geostatistical modelling of onchocerciasis prevalence in Nigeria to support elimination efforts.PLoS neglected tropical diseases · 2026Article
- Article
- Performance of novel onchocerciasis rapid diagnostic tests in a field setting in South Sudan.PLoS neglected tropical diseases · 2025Article
- Enigmatic intractable Epilepsy patients have antibodies that bind glutamate receptor peptides, kill neurons, damage the brain, and cause Generalized Tonic Clonic Seizures.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Model-Based Geostatistical Mapping of the Prevalence of Onchocerca volvulus in Cameroon between 1971 and 2020.PLoS neglected tropical diseases · 2025Article
- Pregnant Women, a Potential Reservoir for Onchocerca volvulus? A Cross Sectional Study in Maridi County, South Sudan.Journal of epidemiology and global health · 2025Article
- Community awareness and neuroepidemiology of onchocerciasis-associated epilepsy in two rural communities in Cameroon.The Pan African medical journal · 2025Article
- Prevalence of onchocerciasis and epilepsy in a Tanzanian region after a prolonged community-directed treatment with ivermectin.PLoS neglected tropical diseases · 2024Article
- Active infection with Onchocerca volvulus and the linkage to epilepsy/nodding syndrome.PLoS neglected tropical diseases · 2024Article
- Review of epilepsy care in the Democratic Republic of the Congo.Epilepsia open · 2024Review
- Chorioretinitis among Immigrant and Travellers. Comment on Mansour et al. Presumed Onchocerciasis Chorioretinitis Spilling over into North America, Europe and Middle East.Diagnostics (Basel, Switzerland) · 2024Article
- Mvolo County, an Onchocerciasis Endemic Area in Western Equatoria State, South Sudan: An Entomological Study to Prepare for a "Slash and Clear" Community-Based Vector Control Intervention.Research and reports in tropical medicine · 2024Article
- Cytotaxonomic characterization and estimation of migration patterns of onchocerciasis vectors (Simulium damnosum sensu lato) in northwestern Ethiopia based on RADSeq data.PLoS neglected tropical diseases · 2024Article
- Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns.PLoS neglected tropical diseases · 2023Article
- AssessingPathogens (Basel, Switzerland) · 2023Article
- Nodding syndrome, a case-control study in Mahenge, Tanzania: Onchocerca volvulus and not Mansonella perstans as a risk factor.PLoS neglected tropical diseases · 2023Article
- Comparison of Structural Changes in Nodding Syndrome and Other Epilepsies Associated WithNeurology(R) neuroimmunology & neuroinflammation · 2023Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
Abstract
A high prevalence of epilepsy is reported in many onchocerciasis-endemic regions. In this paper we discuss recent epidemiological and clinical aspects as well as public health implications of onchocerciasis-associated epilepsy (OAE) and propose a strategy to reduce the burden of disease. OAE probably presents in a variety of clinical manifestations, including the nodding syndrome and the Nakalanga syndrome. The most common clinical presentation, however, is generalized (primarily tonic-clonic) seizures. A characteristic of OAE is the onset of seizures between the ages of 3 and 18 years and clustering in certain families and villages close to rapid-flowing black-fly-infested rivers. A strategy combining active surveillance for epilepsy with early treatment with antiepileptic drugs and prevention of onchocerciasis by increasing the geographical and therapeutic coverage of community-directed treatment with ivermectin (CDTi) may considerably decrease the burden of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.