ReviewJournal of pain research2018
Optimal management of orthodontic pain.
Review in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Photobiomodulation on Pain During Orthodontic Treatment
An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and pain perception in human studies: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- The effect of pharmacological and non-pharmacological interventions on pain control after orthodontic treatment: a systematic review and network meta-analysis.BMC oral health · 2026Pooled it
- Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial.Clinical and experimental dental research · 2025Trial
- Comparative efficacy of pharmaceutical (Ibuprofen) and non-pharmaceutical (photobiomodulation, and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients: a randomized clinical trial.Lasers in medical science · 2024Trial
- Clinical study on the efficacy of LED phototherapy for pain control in an orthodontic procedure.Lasers in medical science · 2019Trial
- Low-level laser therapy (830 nm) on orthodontic pain: blinded randomized clinical trial.Lasers in medical science · 2019Trial
- Elevated TRPV1 expression in the central nucleus of the amygdala participates in initial pain and subsequent anxiety-related behaviors in mice undergoing orthodontic tooth movement.BMC oral health · 2026Article
- Pharmacological Modulation of Orthodontic Tooth Movement: Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. A Review.Clinical, cosmetic and investigational dentistry · 2026Review
- Increased Expression of TRPV1 in the Central Nucleus of the Amygdala Is Involved in Orthodontic Pain in Rats.International journal of molecular sciences · 2025Article
- Orthodontic pain is related to oral health-related quality of life in orthodontic patients.Journal of orthodontic science · 2024Article
- Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives.Journal of Zhejiang University. Science. B · 2023Review
- Article
- The Effectiveness of Low-Level Laser Therapy in Pain Induced by Orthodontic Separator Placement: A Systematic Review.Journal of lasers in medical sciences · 2021Review
- Article
- The central nucleus of the amygdala lesion attenuates orthodontic pain during experimental tooth movement in rats.Brain and behavior · 2020Article
- Comparison of the Perception of Pain during Fixed Orthodontic Treatment with Metal and Ceramic Brackets.Journal of pharmacy & bioallied sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is an undesirable side effect of orthodontic tooth movement, which causes many patients to give up orthodontic treatment or avoid it altogether. The aim of this study was to investigate, through an analysis of the scientific literature, the best method for managing orthodontic pain. The methodological aspects involved careful definition of keywords and diligent search in databases of scientific articles published in the English language, without any restriction of publication date. We recovered 1281 articles. After the filtering and classification of these articles, 56 randomized clinical trials were selected. Of these, 19 evaluated the effects of different types of drugs for the control of orthodontic pain, 16 evaluated the effects of low-level laser therapy on orthodontic pain, and 21 evaluated other methods of pain control. Drugs reported as effective in orthodontic pain control included ibuprofen, paracetamol, naproxen sodium, aspirin, etoricoxib, meloxicam, piroxicam, and tenoxicam. Most studies report favorable outcomes in terms of alleviation of orthodontic pain with the use of low-level laser therapy. Nevertheless, we noticed that there is no consensus, both for the drug and for laser therapy, on the doses and clinical protocols most appropriate for orthodontic pain management. Alternative methods for orthodontic pain control can also broaden the clinician's range of options in the search for better patient care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.