Evidence map›Paper›PMID 29588592›Full record

ArticleNeuropsychiatric disease and treatment2018

Continuous performance task in ADHD: Is reaction time variability a key measure?

Florence Levy, Andrew Pipingas, Elizabeth V Harris, Maree Farrow, Richard B Silberstein

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In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. A novel approach to intra-individual performance variability in ADHD.European child & adolescent psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Florence LevySchool of Psychiatry, University of New South Wales and Head, Child and Family East, Prince of Wales Hospital, Sydney, NSW, Australia.
Andrew PipingasCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Elizabeth V HarrisCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Maree FarrowWicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
Richard B SilbersteinCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the use of the Continuous Performance Task (CPT) reaction time variability (intraindividual variability or standard deviation of reaction time), as a measure of vigilance in attention-deficit hyperactivity disorder (ADHD), and stimulant medication response, utilizing a simple CPT X-task vs an A-X-task.

methodComparative analyses of two separate X-task vs A-X-task data sets, and subgroup analyses of performance on and off medication were conducted.

resultsThe CPT X-task reaction time variability had a direct relationship to ADHD clinician severity ratings, unlike the CPT A-X-task. Variability in X-task performance was reduced by medication compared with the children's unmedicated performance, but this effect did not reach significance. When the coefficient of variation was applied, severity measures and medication response were significant for the X-task, but not for the A-X-task.

conclusionThe CPT-X-task is a useful clinical screening test for ADHD and medication response. In particular, reaction time variability is related to default mode interference. The A-X-task is less useful in this regard.

Indexed as

ADHDcontinuous performance taskreaction time variabilitystimulant medication

Identifiers

PMID29588592
PMCPMC5858546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.