Evidence map›Paper›PMID 29588590›Full record

ArticleInternational journal of nanomedicine2018

Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.

Wenting Jiang, Han Wang, Yongmei Cui, Yiyan Lei, Yuefeng Wang, Di Xu, Neng Jiang, Yangshan Chen, Yu Sun, Yang Zhang and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Detection of HER2ChemMedChem · 2020
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Wenting Jiang *Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Han Wang *Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yongmei Cui *Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yiyan LeiDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yuefeng WangDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Di XuDepartment of Thoracic Surgery, The Central Hospital of Wuhan, Jiang'an District, Wuhan, Hubei, China.
Neng JiangDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yangshan ChenDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yu SunDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yang ZhangBiomedical Engineering, The University of Texas at El Paso, El Paso, TX, USA.
Jessica CaoCumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Zunfu KeDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Sun Yat-sen University · CNCentral Hospital of Wuhan · CNThe University of Texas at El Paso · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating tumor cells (CTCs) detection, an approach considered to be "liquid biopsy", is a potential alternative method in clinical use for early diagnosis of solid tumor progression.

methodsIn this study, we developed a poly (lactic-

resultsPN-NanoVelcro chip exhibits great performance in capture efficiency and high purity. The genetic analysis results showed that most EGFR mutation in tumor tissue could also be detected in CTCs.

conclusionCompared to computed tomography image results, CTC detection can be implemented throughout the course of diseases and provides an accurate and earlier diagnosis of tumor progression, which make it possible for patients to acquire suitable and timely treatment.

Indexed as

AdenocarcinomaAdenocarcinoma of LungBase SequenceCarcinoma, Non-Small-Cell LungCell CountCell Line, TumorDNA Mutational AnalysisDrug Resistance, NeoplasmErbB ReceptorsExonsGefitinibHumansLactic AcidLung NeoplasmsMaleMicroarray AnalysisErbB ReceptorsGefitinibLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerQuinazolinesCTCsEGFR mutationlung adenocarcinomaPN-NanoVelcro chipprognosis

Identifiers

PMID29588590
PMCPMC5862013
OpenAlexW2789482226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.