ArticleScientific reports2018
Transcriptome-wide mapping of signaling pathways and early immune responses in lumpfish leukocytes upon in vitro bacterial exposure.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Hepatic melanomacrophage centers in the arctic cultured fishAquaculture (Amsterdam, Netherlands) · 2024Article
- Teleost Eye Is the Portal of IHNV Entry and Contributes to a Robust Mucosal Immune Response.International journal of molecular sciences · 2023Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- Transcriptome-wide analyses of early immune responses in lumpfish leukocytes upon stimulation with poly(I:C).Frontiers in immunology · 2023Article
- Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure.Frontiers in cellular and infection microbiology · 2023Article
- Multi-Organ Transcriptome Response of Lumpfish (Microorganisms · 2022Article
- Immune Response and Apoptosis-Related Pathways Induced byPathogens (Basel, Switzerland) · 2021Article
- Oral Immunization of Larvae and Juvenile of Lumpfish (Vaccines · 2021Article
- Identification and Expression Profiling of Toll-Like Receptors of Brown Trout (International journal of molecular sciences · 2020Article
- Interleukin-1 Ligands and Receptors in Lumpfish (Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed RNA sequencing, identified components of the immune system and mapped early immune responses of lumpfish (Cyclopterus lumpus) leukocytes following in vitro exposure to the pathogenic bacterium Vibrio anguillarum O1. This is the first characterization of immune molecules in lumpfish at the gene level. In silico analyses revealed that genes encoding proteins involved in pathogen recognition, cell signaling and cytokines in mammals and teleosts are conserved in lumpfish. Unique molecules were also identified. Pathogen recognition components include 13 TLRs, several NLRs and complement factors. Transcriptome-wide analyses of immune responses 6 and 24 hours post bacterial exposure revealed differential expression of 9033 and 15225 genes, respectively. These included TLR5S, IL-1β, IL-8, IL-6, TNFα, IL-17A/F3, IL-17C and several components of the complement system. The data generated will be valuable for comparative studies and make an important basis for further functional analyses of immune and pathogenicity mechanisms. Such knowledge is also important for design of immunoprophylactic measures in lumpfish, a species of fish now farmed intensively for use as cleaner-fish in Atlantic salmon (Salmo salar) aquaculture.
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