ArticleScientific reports2018
Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 123 citations in OpenAlex.
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- Mycotoxins-contaminated wheat matrices bioconversion by Tenebrio molitor larvae (Coleoptera: Tenebrionidae).Insect science · 2026Article
- Multi-mycotoxin biomonitoring in Italian adults: Revealing the connection between diet habits and mycotoxin exposure.Environment international · 2026Article
- Aflatoxin BJournal of fungi (Basel, Switzerland) · 2026Article
- A comparative study of urinary mycotoxin biomarkers co-occurrence patterns and cumulative risk assessment in population from three typical areas in China.Journal of exposure science & environmental epidemiology · 2026Article
- Human biomonitoring of mycotoxins: key challenges and future directions.Mycotoxin research · 2025Review
- Review
- Integrative human intervention study for mycotoxin biomarker discovery and toxicokinetic characterization.Scientific reports · 2025Article
- Derivation of human toxicokinetic parameters and internal threshold of toxicological concern for tenuazonic acid through a human intervention trial and hierarchical Bayesian population modeling.Journal of exposure science & environmental epidemiology · 2025Article
- Mycotoxins - Determination of deoxynivalenol and deepoxydeoxynivalenol in urine by LC-MS/MS: Biomonitoring Method - Translation of the German version from 2025.The MAK collection for occupational health and safety · 2025Article
- Cross-sectional biomonitoring of urinary deoxynivalenol, T-2 and HT-2 toxins, and zearalenone in Japanese adults.Environmental health and preventive medicine · 2025Article
- Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway.Frontiers in public health · 2025Article
- Article
- Development of a high-throughput UHPLC-MS/MS method for the analysis of Fusarium and Alternaria toxins in cereals and cereal-based food.Analytical and bioanalytical chemistry · 2024Article
- PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Assessment of Mycotoxin Exposure and Associated Risk in Pregnant Dutch Women: The Human Biomonitoring Approach.Toxins · 2024Article
- Food Security and Foodborne Mycotoxicoses-What Should Be the Adequate Risk Assessment and Regulation?Microorganisms · 2024Review
- Article
- Dietary mycotoxin exposure and human health risks: A protocol for a systematic review.Environment international · 2024Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside). Twenty volunteers were restricted in consuming cereals and cereal-based foods for 4 days. At day 3, a single bolus of 1 µg/kg body weight of DON and a single bolus of 1 µg/kg body weight of DON-3-glucoside after a washing-out period of two months was administered, and a 24-h urine collection was performed. The urine was analysed for DON, DON-3-glucoside, 3-ADON, 15-ADON, deepoxy-deoxynivalenol (DOM-1), deoxynivalenol-3-glucuronide (DON-3-glucuronide) and deoxynivalenol-15-glucuronide (DON-15-glucuronide). The urinary biomarker-analysis revealed that DON and DON-3-glucoside were rapidly absorbed, distributed, metabolized and excreted. Sixty-four % of the administered DON and 58% of DON-3-glucoside was recovered in the urine collected within 24 h. DON-15-glucuronide was the most prominent urinary biomarker followed by free DON and DON-3-glucuronide. Moreover, correlations among the presence of DON-15-glucuronide and DON-3-glucuronide were observed (within 24 hours (r = 0.61)). The DOM-1 detected in the urine was higher after the DON-3-glucoside administration. The obtained results are imperative to construct a standardized method to estimate DON-intake by means of urinary biomarkers.
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