Evidence map›Paper›PMID 29588408›Full record

ArticlemBio2018

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs.

Carmen Herrero-de-Dios, Alison M Day, Anna T Tillmann, Stavroula L Kastora, David Stead, Paula S Salgado, Janet Quinn, Alistair J P Brown

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A COmBio · 2024
    Article
  5. Article
  6. Article
  7. Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022
    Review
  8. Review
  9. Article
  10. Deletion of theFrontiers in cellular and infection microbiology · 2021
    Article
  11. Hog1 Controls Lipids Homeostasis Upon Osmotic Stress inJournal of fungi (Basel, Switzerland) · 2020
    Article
  12. Article
  13. HGT in the human and skin commensalProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. Article
  16. Deletion of theJournal of fungi (Basel, Switzerland) · 2019
    Article
  17. Review
  18. Stress-Activated Protein Kinases in Human Fungal Pathogens.Frontiers in cellular and infection microbiology · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Carmen Herrero-de-DiosAberdeen Fungal Group, MRC Centre for Medical Mycology, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom.
Alison M DayInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Anna T Tillmann *Aberdeen Fungal Group, MRC Centre for Medical Mycology, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom.
Stavroula L Kastora *Aberdeen Fungal Group, MRC Centre for Medical Mycology, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom.
David SteadAberdeen Proteomics, University of Aberdeen, Rowett Institute, Aberdeen, United Kingdom.
Paula S SalgadoInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Janet QuinnInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Alistair J P BrownAberdeen Fungal Group, MRC Centre for Medical Mycology, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom al.brown@abdn.ac.uk.
University of Aberdeen · GBNewcastle University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/F00513X/1Biotechnology and Biological Sciences Research Council BB/K016393/1Biotechnology and Biological Sciences Research Council BB/K017365/1Medical Research Council MR/M000923/1Medical Research Council MR/M026663/1Medical Research Council MR/N006364/1Wellcome TrustWellcome Trust 097377
6 · The paper itself

Abstract

In all eukaryotic kingdoms, mitogen-activated protein kinases (MAPKs) play critical roles in cellular responses to environmental cues. These MAPKs are activated by phosphorylation at highly conserved threonine and tyrosine residues in response to specific inputs, leading to their accumulation in the nucleus and the activation of their downstream targets. A specific MAP kinase can regulate different downstream targets depending on the nature of the input signal, thereby raising a key question: what defines the stress-specific outputs of MAP kinases? We find that the Hog1 MAPK contributes to nitrosative-stress resistance in

Indexed as

Candida albicansGene Expression Regulation, FungalMitogen-Activated Protein KinasesNitrosative StressOxidation-ReductionPhosphorylationMitogen-Activated Protein KinasesCandida albicansMAP kinase signalingnitrosative stress

Identifiers

PMID29588408
PMCPMC5874921
OpenAlexW2789357295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.