Evidence map›Paper›PMID 29588406›Full record

ArticlemBio2018

Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen

Sarah Inglesfield, Aleksandra Jasiulewicz, Matthew Hopwood, James Tyrrell, George Youlden, Maria Mazon-Moya, Owain R Millington, Serge Mostowy, Sara Jabbari, Kerstin Voelz

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Molecular mechanisms that govern infection and antifungal resistance in Mucorales.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  2. IntegratingCurrent research in microbial sciences · 2024
    Article
  3. AlternativeFrontiers in cellular and infection microbiology · 2024
    Review
  4. Review
  5. Article
  6. A Fun-Guide to Innate Immune Responses to Fungal Infections.Journal of fungi (Basel, Switzerland) · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Mucorales Species and Macrophages.Journal of fungi (Basel, Switzerland) · 2020
    Review
  11. Review
  12. Article
  13. Article
  14. Animal Models to Study Mucormycosis.Journal of fungi (Basel, Switzerland) · 2019
    Review
  15. mBio · 2019
    Article
  16. The Zebrafish as a Model Host for Invasive Fungal Infections.Journal of fungi (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah Inglesfield *Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Aleksandra Jasiulewicz *Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Matthew HopwoodSchool of Mathematics, University of Birmingham, Birmingham, United Kingdom.
James TyrrellSchool of Mathematics, University of Birmingham, Birmingham, United Kingdom.
George YouldenInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Maria Mazon-MoyaSection of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Owain R MillingtonStrathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Serge MostowySection of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.ORCID 0000-0002-7286-6503
Sara JabbariInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom S.Jabbari@bham.ac.uk K.Voelz@bham.ac.uk.
Kerstin VoelzInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom S.Jabbari@bham.ac.uk K.Voelz@bham.ac.uk.
University of Birmingham · GBImperial College London · GBUniversity of Strathclyde · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M021386/1Wellcome Trust 108387/Z/15/ZWellcome Trust 108871Wellcome Trust 1516ISSFFEL9Wellcome Trust 206444/Z/17/ZWellcome Trust WT097411MA
6 · The paper itself

Abstract

Mucormycosis is an emerging fungal infection with extremely high mortality rates in patients with defects in their innate immune response, specifically in functions mediated through phagocytes. However, we currently have a limited understanding of the molecular and cellular interactions between these innate immune effectors and mucormycete spores during the early immune response. Here, the early events of innate immune recruitment in response to infection by

Indexed as

AnimalsDexamethasoneGranulomaHost-Pathogen InteractionsImmunity, InnateModels, TheoreticalMucorNeutrophilsPhagocytesZebrafishDexamethasonefungal infectionfungal pathogenesishost-pathogen interactionsinnate immunitymacrophagesmathematical modelingmucormycosisneutrophilsphagocyteszebrafish

Identifiers

PMID29588406
PMCPMC5874920
OpenAlexW2794125975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.