Evidence map›Paper›PMID 29588402›Full record

ArticlemBio2018

Cyclic di-AMP Acts as an Extracellular Signal That Impacts

Loni Townsley, Sarah M Yannarell, Tuanh Ngoc Huynh, Joshua J Woodward, Elizabeth A Shank

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Root colonization by beneficial rhizobacteria.FEMS microbiology reviews · 2024
    Pooled it
  2. O-Glycosylated expansinScience advances · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Staying in the loop to make ends meet: roles and regulation of GlmR inbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. The extracytoplasmic sigma factor σScientific reports · 2025
    Article
  9. Optimizing surfactin yield inFrontiers in microbiology · 2025
    Article
  10. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Loni TownsleyDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sarah M YannarellDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tuanh Ngoc HuynhDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Elizabeth A ShankDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA eshank@unc.edu.ORCID 0000-0002-4804-1966
University of North Carolina at Chapel Hill · USUniversity of Washington · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Using Co-culture and Bioinformatics to Discover New Antibiotic BioactivitiesR01GM112981 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHANK, ELIZABETH ANNE · 2016 to 2020
$1.4M
NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM112981
6 · The paper itself

Abstract

There is a growing appreciation for the impact that bacteria have on higher organisms. Plant roots often harbor beneficial microbes, such as the Gram-positive rhizobacterium

Indexed as

ArabidopsisBacillus subtilisBacterial ProteinsBiofilmsCyclic AMPPlant RootsBacterial ProteinsCyclic AMPArabidopsis thalianaBacillus subtilisbiofilmscell-cell interactioncyclic di-AMPplant-microbe interactions

Identifiers

PMID29588402
PMCPMC5874923
OpenAlexW2789890246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.