Evidence map›Paper›PMID 29588397›Full record

ArticleJournal of cell science2018

Loss of PTEN promotes formation of signaling-capable clathrin-coated pits.

Luciana K Rosselli-Murai, Joel A Yates, Sei Yoshida, Julia Bourg, Kenneth K Y Ho, Megan White, Julia Prisby, Xinyu Tan, Megan Altemus, Liwei Bao and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Distinct early role of PTEN regulation during HCMV infection of monocytes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. PTEN: Bridging Endocytosis and Signaling.Cold Spring Harbor perspectives in medicine · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Luciana K Rosselli-MuraiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Joel A YatesDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-5624, USA.
Sei YoshidaDepartment of Microbiology and Immunology of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-5620, USA.
Julia BourgDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109-1055, USA.
Kenneth K Y HoDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Megan WhiteDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Julia PrisbyDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Xinyu TanDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Megan AltemusDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-5624, USA.
Liwei BaoDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-5624, USA.
Zhi-Fen WuDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-5624, USA.
Sarah L VeatchDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109-1055, USA.
Joel A SwansonDepartment of Microbiology and Immunology of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109-5620, USA.
Sofia D MerajverDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109-5624, USA smerajve@umich.edu allenliu@umich.edu.
Allen P LiuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA smerajve@umich.edu allenliu@umich.edu.ORCID 0000-0002-0309-7018
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
The Regulation of MacropinocytosisR01GM110215 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, JOEL A · 2014 to 2017
$1.3M
NCI NIH HHS P30 CA046592NCI NIH HHS T32 CA009676NIGMS NIH HHS R01 GM110215
6 · The paper itself

Abstract

Defective endocytosis and vesicular trafficking of signaling receptors has recently emerged as a multifaceted hallmark of malignant cells. Clathrin-coated pits (CCPs) display highly heterogeneous dynamics on the plasma membrane where they can take from 20 s to over 1 min to form cytosolic coated vesicles. Despite the large number of cargo molecules that traffic through CCPs, it is not well understood whether signaling receptors activated in cancer, such as epidermal growth factor receptor (EGFR), are regulated through a specific subset of CCPs. The signaling lipid phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P

Indexed as

Coated Pits, Cell-MembraneErbB ReceptorsHumansPTEN PhosphohydrolaseSignal TransductionErbB ReceptorsPTEN PhosphohydrolasePTEN protein, humanClathrin-mediated endocytosisEGFR signalingPhosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3]PTEN

Identifiers

PMID29588397
PMCPMC5963840
OpenAlexW2794645836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.