Evidence map›Paper›PMID 29588367›Full record

ArticleThe Journal of biological chemistry2018

A cassette of basic amino acids in histone H2B regulates nucleosome dynamics and access to DNA damage.

Yesenia Rodriguez, Mingrui Duan, John J Wyrick, Michael J Smerdon

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. DNA Repair in Nucleosomes: Insights from Histone Modifications and Mutants.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Generation of Recombinant Nucleosomes Containing Site-Specific DNA Damage.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yesenia RodriguezFrom Biochemistry and Biophysics, School of Molecular Biosciences, Pullman, Washington 99164-7520.
Mingrui DuanFrom Biochemistry and Biophysics, School of Molecular Biosciences, Pullman, Washington 99164-7520.
John J WyrickFrom Biochemistry and Biophysics, School of Molecular Biosciences, Pullman, Washington 99164-7520; Center for Reproductive Biology, Washington State University, Pullman, Washington 99164-7520.
Michael J SmerdonFrom Biochemistry and Biophysics, School of Molecular Biosciences, Pullman, Washington 99164-7520. Electronic address: smerdon@wsu.edu.
Washington State University · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
DNA REPAIR IN A HORMONE-RESPONSIVE GENER01ES004106 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J · 1986 to 2014
$4.5M
Repair of Carcinogen Damaged DNA in Human ChromatinR37ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J · 2001 to 2010
$4.0M
REPAIR OF CARCINOGEN-DAMAGED DNA IN HUMAN CHROMATINR01ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J, WYRICK, JOHN J · 1985 to 2015
$2.5M
Genome-wide analysis of UV damage formation, repair, and mutagenesisR21ES027937 · NIEHS · WASHINGTON STATE UNIVERSITY · PI ROBERTS, STEVEN A, WYRICK, JOHN J · 2017 to 2018
$419k
NIEHS NIH HHS R01 ES002614NIEHS NIH HHS R01 ES004106NIEHS NIH HHS R21 ES027937NIEHS NIH HHS R37 ES002614NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Nucleosome dynamics, such as spontaneous DNA unwrapping, are postulated to have a critical role in regulating the access of DNA repair machinery to DNA lesions within nucleosomes. However, the specific histone domains that regulate nucleosome dynamics and the impact of such changes in intrinsic nucleosome dynamics on DNA repair are not well understood. Previous studies identified a highly conserved region in the N-terminal tail of histone H2B known as the

Indexed as

DNA DamageAmino Acids, BasicAnimalsDNADNA Polymerase betaDNA RepairFluorescence Resonance Energy TransferHistone CodeHistonesNucleosomesProtein Interaction Domains and MotifsUracilUracil-DNA GlycosidaseXenopus laevisAmino Acids, BasicDNADNA Polymerase betaHistonesNucleosomesUracilUracil-DNA Glycosidasebase excision repair (BER)chromatinDNA repairglycosylaseHBR domainhistone H2B repressionhistone modificationnucleosomepolymerase beta

Identifiers

PMID29588367
PMCPMC5949990
OpenAlexW2794848326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.