ArticleThe Journal of experimental medicine2018
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division.
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Atomistic TCR-ligand interactions instruct memory T-cell differentiation.bioRxiv : the preprint server for biology · 2025Article
- Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.Science (New York, N.Y.) · 2025Article
- Systems immunology of regulatory T cells: can one circuit explain it all?Trends in immunology · 2023Review
- Toll-like receptors control the accumulation of neutrophils in lymph nodes that expand CD4European journal of immunology · 2023Article
- Insights into dendritic cell maturation during infection with application of advanced imaging techniques.Frontiers in cellular and infection microbiology · 2023Review
- T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV.Brain, behavior, & immunity - health · 2022Article
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- An update on the use of cryoablation and immunotherapy for breast cancer.Frontiers in immunology · 2022Review
- T cell kinetics reveal expansion of distinct lung T cell subsets in acute versus in resolved influenza virus infection.Frontiers in immunology · 2022Article
- Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses.European journal of immunology · 2021Review
- Motility Matters: How CD8Cold Spring Harbor perspectives in biology · 2021Review
- The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.The Journal of experimental medicine · 2021Article
- Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen.The Journal of experimental medicine · 2020Article
- CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity.Trends in immunology · 2020Review
- Quorum sensing via dynamic cytokine signaling comprehensively explains divergent patterns of effector choice among helper T cells.PLoS computational biology · 2020Article
- Cytoskeletal tension actively sustains the migratory T-cell synaptic contact.The EMBO journal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells are primed in secondary lymphoid organs by establishing stable interactions with antigen-presenting cells (APCs). However, the cellular mechanisms underlying the termination of T cell priming and the initiation of clonal expansion remain largely unknown. Using intravital imaging, we observed that T cells typically divide without being associated to APCs. Supporting these findings, we demonstrate that recently activated T cells have an intrinsic defect in establishing stable contacts with APCs, a feature that was reflected by a blunted capacity to stop upon T cell receptor (TCR) engagement. T cell unresponsiveness was caused, in part, by a general block in extracellular calcium entry. Forcing TCR signals in activated T cells antagonized cell division, suggesting that T cell hyporesponsiveness acts as a safeguard mechanism against signals detrimental to mitosis. We propose that transient unresponsiveness represents an essential phase of T cell priming that promotes T cell disengagement from APCs and favors effective clonal expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.