Evidence map›Paper›PMID 29588346›Full record

ArticleThe Journal of experimental medicine2018

Microbial symbionts regulate the primary Ig repertoire.

Yuezhou Chen, Neha Chaudhary, Nicole Yang, Alessandra Granato, Jacob A Turner, Shannon L Howard, Colby Devereaux, Teng Zuo, Akritee Shrestha, Rishi R Goel and 2 more

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
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  11. Article
  12. Review
  13. Omics in gut microbiome analysis.Journal of microbiology (Seoul, Korea) · 2021
    Review
  14. Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  15. Review
  16. Article
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  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuezhou ChenDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Neha ChaudharyDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Nicole YangDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0003-0817-5457
Alessandra GranatoDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jacob A TurnerDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Shannon L HowardDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Colby DevereauxDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Teng ZuoDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Akritee ShresthaDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Rishi R GoelDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Donna NeubergDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA.
Duane R WesemannDepartment of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA dwesemann@bwh.harvard.edu.ORCID 0000-0002-6690-944X

Funding

IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
Discovering the Role of Commensal Microbes on Primary B Lymphocyte DevelopmentR01AI113217 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2015 to 2019
$3.3M
Decrypting IgE B Cell ImmunobiologyR01AI121394 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2016 to 2020
$3.1M
NIAID NIH HHS R01 AI113217NIAID NIH HHS R01 AI121394NIAID NIH HHS T32 AI007306NIH HHS P40 OD010995
6 · The paper itself

Abstract

The ability of immunoglobulin (Ig) to recognize pathogens is critical for optimal immune fitness. Early events that shape preimmune Ig repertoires, expressed on IgM

Indexed as

SymbiosisAnimalsBacteriaB-LymphocytesClone CellsGerm-Free LifeImmunity, MucosalImmunoglobulin Heavy ChainsImmunoglobulinsImmunoglobulin Variable RegionIntestine, SmallMice, Inbred C57BLReceptors, Antigen, B-CellSpleenT-LymphocytesImmunoglobulin Heavy ChainsImmunoglobulinsImmunoglobulin Variable RegionReceptors, Antigen, B-Cell

Identifiers

PMID29588346
PMCPMC5940265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.