Evidence map›Paper›PMID 29588343›Full record

ArticleMolecular pharmacology2018

Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of

Justin R King, Aman Ullah, Ellen Bak, M Saleet Jafri, Nadine Kabbani

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. The cellular model for Alzheimer's disease research: PC12 cells.Frontiers in molecular neuroscience · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Differential Activation and Desensitization States Promoted by NoncanonicalThe Journal of pharmacology and experimental therapeutics · 2022
    Article
  14. Cannabidiol as a modulator of α7 nicotinic receptors.Cellular and molecular life sciences : CMLS · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Therapeutic Targeting ofPharmacological reviews · 2021
    Review
  19. Review
  20. Nicotinic Acetylcholine Receptors of PC12 Cells.Cellular and molecular neurobiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Justin R KingInterdisciplinary Program in Neuroscience (J.R.K., M.S.J., N.K.) and School of Systems Biology (A.U., E.B., M.S.J., N.K.), George Mason University, Fairfax, Virginia.
Aman UllahInterdisciplinary Program in Neuroscience (J.R.K., M.S.J., N.K.) and School of Systems Biology (A.U., E.B., M.S.J., N.K.), George Mason University, Fairfax, Virginia.
Ellen BakInterdisciplinary Program in Neuroscience (J.R.K., M.S.J., N.K.) and School of Systems Biology (A.U., E.B., M.S.J., N.K.), George Mason University, Fairfax, Virginia.
M Saleet JafriInterdisciplinary Program in Neuroscience (J.R.K., M.S.J., N.K.) and School of Systems Biology (A.U., E.B., M.S.J., N.K.), George Mason University, Fairfax, Virginia.
Nadine KabbaniInterdisciplinary Program in Neuroscience (J.R.K., M.S.J., N.K.) and School of Systems Biology (A.U., E.B., M.S.J., N.K.), George Mason University, Fairfax, Virginia nkabbani@gmu.edu.
George Mason University · US

Funding

Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
NHLBI NIH HHS U01 HL116321
6 · The paper itself

Abstract

The pharmacological targeting of the

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsCalciumCalcium SignalingCell Line, TumorCytoplasmGTP-Binding ProteinsHumansIsoxazolesPC12 CellsPhenylurea CompoundsRats1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)ureaalpha7 Nicotinic Acetylcholine ReceptorCalciumGTP-Binding ProteinsIsoxazolesPhenylurea Compounds

Identifiers

PMID29588343
PMCPMC11033947
OpenAlexW2795271020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.